Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blo...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cardiovascular medicine 2012-02, Vol.22 (2), p.35-39
Main Authors: Liu, Nian, Napolitano, Carlo, Venetucci, Luigi A, Priori, Silvia G
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - pharmacokinetics
Anti-Arrhythmia Agents - therapeutic use
Antiarrhythmics
Cardiac arrhythmia
Cardiovascular
Catecholamines
Disease Models, Animal
Flecainide - pharmacokinetics
Flecainide - therapeutic use
Kinases
Mice
Mutation
Myocytes, Cardiac - drug effects
Proteins
Rodents
Tachycardia, Ventricular - drug therapy
Tachycardia, Ventricular - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2012.06.008