Improvement in [beta]-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes

The aim of our study was to evaluate the effect of a lifestyle intervention program on β-cell function and to explore the role of gastrointestinal peptides in subjects with T2D. Subjects with T2D (n=74) received 24weeks of intervention: 12weeks of slimming diet (-500kcal/day) and the subsequent 12we...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2012-09, Vol.26 (5), p.442
Main Authors: Kahleova, H, Mari, A, Nofrate, V, Matoulek, M, Kazdova, L, Hill, M, Pelikanova, T
Format: Article
Language:English
Subjects:
Diabetes
Diet
Insulin
Insulin resistance
Weight control
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Summary:The aim of our study was to evaluate the effect of a lifestyle intervention program on β-cell function and to explore the role of gastrointestinal peptides in subjects with T2D. Subjects with T2D (n=74) received 24weeks of intervention: 12weeks of slimming diet (-500kcal/day) and the subsequent 12weeks of diet were combined with aerobic exercise. All subjects were examined at weeks 0, 12 and 24. β-cell function was assessed during standard meal tests. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution, and β-cell function was quantified with a mathematical model. Plasma concentrations of gastrointestinal peptides were measured in a fasting state and during hyperinsulinemia induced by hyperinsulinemic isoglycemic clamp. Mean weight loss was 5.03±4.38kg (p
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2012.05.003