Increased expression of the glucocorticoid receptor [beta]in infants with RSV bronchiolitis

The majority of studies on glucocorticoid treatment in respiratory syncytial virus (RSV) bronchiolitis concluded that there are no beneficial effects. We hypothesized that RSV-infected patients may have an increased glucocorticoid receptor (GR) ... expression, the isoform that is unable to bind cort...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2012-10, Vol.130 (4), p.e804
Main Authors: Diaz, Patricia V, Pinto, Ricardo A, Mamani, Rossana, Uasapud, Paola A, Bono, Maria A, Gaggero, Aldo A, Guerrero, Julia, Goecke, Annelise
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Causes of
Corticosteroids
Cytokines
Gene expression
Glucocorticoids
Health aspects
Hormones
Pediatrics
Polymerase chain reaction
Real time
Respiratory syncytial virus
Respiratory syncytial virus infection
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Summary:The majority of studies on glucocorticoid treatment in respiratory syncytial virus (RSV) bronchiolitis concluded that there are no beneficial effects. We hypothesized that RSV-infected patients may have an increased glucocorticoid receptor (GR) ... expression, the isoform that is unable to bind cortisol and exert an antiinflammatory action. By using real-time polymerase chain reaction, we studied the expression of α and ... GR in the peripheral blood mononuclear cells obtained from 49 RSV-infected infants (
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2012-0160