Diagnosing renal failure due to diethylene glycol in children in a resource-constrained setting

• Published in: Pediatric nephrology (Berlin, West) West), 2012-06, Vol.27 (6), p.1021-1028
• Main Authors: Akuse, Rosamund Modupe, Eke, Felicia Uchezuba, Ademola, Adebowale Dele, Fajolu, Iretiola Bamikeolu, Gbelee, Henry Olusegun, Ihejiahi, Ugochi, Bugaje, Mairo Adamu, Anochie, Ifoema Comfort, Asinobi, Adanze Onyenonachi, Okafor, Henrietta Uchenna, Adeleke, Solomon Ibiyemi, Audu, Lamidi Isah, Otuneye, Adekunle, Disu, Elizabeth, Idris, Hafsat, Aikhonbare, Henry, Yakubu, Alhassan, Ogala, William, Ogunrinde, Olufemi, Wammanda, Robinson, Orogade, Adeola, Anyiam, Jane, Eseigbe, Edwin, Umar, Lawal, Musa, Hafsat, Onalo, Richard, West, Boma, Paul, Nsirimobu, Lesi, Folusho, Ladapo, Taiwo, Boyede, Ojombo, Okeowo, Rahmon, Mustapha, Akeem, Akinola, Ibironke, Chima-Oduko, Oma, Awobusuyi, Olugbenga
• Format: Article
• Language: English
• Subjects: Acidosis; Acidosis - chemically induced; Acidosis - diagnosis; Analgesics; Analgesics - chemistry; Analgesics - therapeutic use; Chi-Square Distribution; Child; Child, Preschool; Children; Developing Countries - economics; Drug Combinations; Drug Contamination; Epidemics; Ethylene Glycols - analysis; Ethylene Glycols - poisoning; Female; Glycols; Health Care Costs; Hemodialysis; Humans; Infant; Kidney Function Tests - economics; Kidneys; Male; Manufacturing; Medical History Taking; Medical records; Medicine; Medicine & Public Health; Metabolism; Multiple Organ Failure - chemically induced; Multiple Organ Failure - diagnosis; Nephrology; Nigeria - epidemiology; Original Article; Pediatrics; Peritoneal dialysis; Poisoning; Poisoning - diagnosis; Poisoning - economics; Poisoning - etiology; Predictive Value of Tests; Prognosis; Renal Dialysis - economics; Renal Insufficiency - chemically induced; Renal Insufficiency - diagnosis; Renal Insufficiency - economics; Renal Insufficiency - epidemiology; Renal Insufficiency - therapy; Risk Assessment; Risk Factors; Teaching hospitals; Time Factors; Tooth Eruption - drug effects; Training; Urology
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-011-2082-8

Background In 2008, several Nigerian children developed acute kidney injury (AKI) after ingesting teething syrup contaminated with diethylene glycol (DEG). Because there are limited diagnostic facilities in resource-constrained countries, this study investigated whether AKI associated with DEG could be identified by other means. Methods This was a multicenter study. Information was obtained from hospital records. Clinicopathological features of all children with AKI over a 6-month period were reviewed. Results Sixty (50.4%) of 119 children ingested “ My pikin” teething syrup. Compared to children who had not ingested it, they were significantly ( p