Renal function, renal volume, and blood pressure in infants with antecedent of antenatal steroids

• Published in: Pediatric nephrology (Berlin, West) West), 2011-10, Vol.26 (10), p.1851-1856
• Main Authors: Carballo-Magdaleno, Deyanira, Guízar-Mendoza, Juan M., Amador-Licona, Norma, Domínguez-Domínguez, Víctor
• Format: Article
• Language: English
• Subjects: Age; beta 2-Microglobulin - analysis; Birth Weight; Blood pressure; Blood Pressure - physiology; Body Weight - drug effects; Child, Preschool; Creatinine; Cystatin C - blood; Female; Fetuses; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Infants; Insulin resistance; Kidney - anatomy & histology; Kidney - diagnostic imaging; Kidney - physiology; Kidney Function Tests; Male; Medicine & Public Health; Nephrology; Newborn babies; Original Article; Pediatrics; Premature babies; Prenatal Care; Prospective Studies; Sex Factors; Steroids; Steroids - adverse effects; Steroids - therapeutic use; Ultrasonic imaging; Ultrasonography; Urology
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-011-1860-7

Steroids have been used for more than 20 years in preterm infants to induce pulmonary maturity; however, some long-term effects have been reported, such as insulin resistance and elevation of blood pressure. The aim of our study was to compare renal volume, renal function, and blood pressure in infants between 12–36 months of age with and without antecedent of antenatal steroid treatment. This was a cross-sectional study comprised of three groups of infants ( n  = 30, respectively): preterm infants with and without antecedent of receiving antenatal steroids, respectively, and full-term infants. Blood pressure, renal volume, glomerular filtration rate, and tubular function were measured. Blood pressure and cystatin C levels and glomerular filtration rate were higher in both groups of preterm infants than in the control group ( p