Evaluation of sialic acids, TNF-[alpha], INF-[gamma], and acute-phase proteins in cattle infected with foot-and-mouth disease

The present study was conducted to evaluate the concentrations of sialic acids, tumor necrosis factor-alpha (TNF-α), and gamma-interferon (INF-γ) and their correlation with acute-phase proteins (haptoglobin, serum amyloid A, ceruloplasmin, and fibrinogen) in cattle infected with foot-and-mouth disea...

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Bibliographic Details
Published in:Comparative clinical pathology 2012-02, Vol.21 (1), p.23
Main Authors: Nazifi, Saeed, Ansari-lari, Maryam, Ghafari, Narjes, Mohtarami, Somayeh, Ghezelbash, Amir, Tabandeh, Mohammad Reza
Format: Article
Language:English
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Summary:The present study was conducted to evaluate the concentrations of sialic acids, tumor necrosis factor-alpha (TNF-α), and gamma-interferon (INF-γ) and their correlation with acute-phase proteins (haptoglobin, serum amyloid A, ceruloplasmin, and fibrinogen) in cattle infected with foot-and-mouth disease (FMD). Thirty cows were diagnosed and confirmed for FMD. Ten clinically healthy adult cattle were selected as a control group. Serum haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin, fibrinogen, total sialic acid (TSA), lipid-bound sialic acid (LBSA), protein-bound sialic acid (PBSA), TNF-α, and INF-γ were measured by validated standard methods. All parameters were significantly higher in the diseased animals compared with the healthy group (P
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-010-1059-5