Relationship between upper gastrointestinal bleeding and non steroidal anti-inflammatory drugs in children

The authors evaluated the relationship between drug intake and upper gastrointestinal (GI) bleeding. The endoscopic files of the previous 2 years were reviewed and the incidence and age and sex distribution recorded. GI bleeding is indication for a high percentage of lower endoscopies and a low perc...

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Bibliographic Details
Published in:Pediatric surgery international 1997-04, Vol.12 (4), p.264-265
Main Authors: LI VOTI, G, ACIERNO, C, TULONE, V, CATALIOTTI, F
Format: Article
Language:English
Subjects:
Acetaminophen - adverse effects
Analgesics, Non-Narcotic - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Biological and medical sciences
Child, Preschool
Children & youth
Digestive system
Drug toxicity and drugs side effects treatment
Female
Gastritis - chemically induced
Gastritis - epidemiology
Hematemesis - chemically induced
Hematemesis - epidemiology
Hemorrhage
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Retrospective Studies
Toxicity: digestive system
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Summary:The authors evaluated the relationship between drug intake and upper gastrointestinal (GI) bleeding. The endoscopic files of the previous 2 years were reviewed and the incidence and age and sex distribution recorded. GI bleeding is indication for a high percentage of lower endoscopies and a low percentage of upper endoscopies. On the other hand, although rarer upper GI bleeding is more severe and frequently related to drug ingestion. About 50% of cases showed gastric erosions secondary to drug intake. A relation between gastric bleeding and paracetamol is considered, as is the possibility of preventing secondary severe bleeding by pharmacologic gastric protection in children with risk factors such as chronic use of other drugs or portal hypertension.
ISSN:0179-0358
1437-9813
DOI:10.1007/BF01372146