Antioxidant protection of the brain in rats during acute stress and administration of interleukin-1[beta]

• Published in: Bulletin of experimental biology and medicine 2012-09, Vol.153 (5), p.680
• Main Authors: Kalinichenko, L.S, Pertsov, S.S, Koplik, E.V, Pirogova, G.V
• Format: Article
• Language: English
• Subjects: Antioxidants; Enzymes; Interleukins; Stress (Psychology); Superoxide
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1798-1

We studied the effect of IL-1[beta] on antioxidant enzyme activity in emotiogenic structures of the brain (hypothalamus, sensorimotor cortex, and amygdala) in behaviorally passive and active rats with different sensitivity to stress. One-hour immobilization of animals with simultaneous electrocutaneous stimulation was used as a model of stress. An intraperitoneal injection of IL-1[beta] (5 [micro]g/kg) was followed by the decrease in glutathione reductase activity in the hypothalamus of rats. Behaviorally active animals of the IL-1[beta] group were characterized by an increase in the activities of Cu/Zn superoxide dismutase and glutathione peroxidase in the sensorimotor cortex and amygdala, respectively. IL-1[beta] administration was accompanied by activation of Cu/Zn superoxide dismutase and glutathione peroxidase in the amygdala of passive rats. Pretreatment with IL-1[beta] abolished the poststress changes in enzyme activity in the hypothalamus and sensorimotor cortex of active and passive rats, respectively. These data illustrate the specific effects of IL-1[beta] on antioxidant protection of CNS tissues in rats with various behavioral characteristics. Key Words: interleukin-1[beta]; emotional stress; antioxidant enzymes; brain; rats with various behavioral characteristics