Sugar-fiber Imprinting to Generate Microgrooves on Polymeric Film Surfaces for Contact Guidance of Cells

Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar-fiber imprinting technique to generate microgroo...

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Bibliographic Details
Published in:Chinese journal of chemistry 2012-10, Vol.30 (10), p.2292-2296
Main Author: 屈泽华 丁建东
Format: Article
Language:English
Subjects:
biomaterials
contact guidance of cells
poly(lactic-co-glycolic acid) (PLGA)
Polymers
sugar fibers
surface modification
印迹聚合物
引导
水性聚合物
沟槽
糖
纤维
细胞
薄膜表面
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Summary:Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar-fiber imprinting technique to generate microgrooves on hydrophobic polymers demonstrated by the poly（lactic-eo-glycolic acid） （PLGA） films. Microgrooves were conveniently generated after removing sugar fibers simply by water. The resulting locally anisotropic microgrooves were confirmed to elongate the cells cultured on the surface.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200841