Hypoxic preconditioning modifies activity of pro- and antioxidant systems in the rat hippocampus

The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2012-10, Vol.6 (4), p.333-337
Main Authors: Kislin, M. S., Stroev, S. A., Gluschenko, T. S., Tyulkova, E. I., Pelto-Huikko, M., Samoilov, M. O.
Format: Article
Language:English
Subjects:
Antioxidants
Bioorganic Chemistry
Brain
Chemistry
Chemistry and Materials Science
Hypoxia
Medicinal Chemistry
Neurochemistry
Rodents
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Summary:The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning trial. In addition, it down regulated the levels of protein antioxidants (Trx-1, Trx-2, Cu,Zn-SOD) and also decreased several lipid peroxidation products 24 h after the preconditioning.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750812040051