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Hypoxic preconditioning modifies activity of pro- and antioxidant systems in the rat hippocampus
The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning...
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Published in: | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2012-10, Vol.6 (4), p.333-337 |
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container_title | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry |
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creator | Kislin, M. S. Stroev, S. A. Gluschenko, T. S. Tyulkova, E. I. Pelto-Huikko, M. Samoilov, M. O. |
description | The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning trial. In addition, it down regulated the levels of protein antioxidants (Trx-1, Trx-2, Cu,Zn-SOD) and also decreased several lipid peroxidation products 24 h after the preconditioning. |
doi_str_mv | 10.1134/S1990750812040051 |
format | article |
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subjects | Antioxidants Bioorganic Chemistry Brain Chemistry Chemistry and Materials Science Hypoxia Medicinal Chemistry Neurochemistry Rodents |
title | Hypoxic preconditioning modifies activity of pro- and antioxidant systems in the rat hippocampus |
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