Enantioselective and a-Regioselective Allylic Amination of Morita-Baylis-Hillman Acetates with Simple Aromatic Amines Catalyzed by Planarly Chiral Ligand/Palladium Catalyst

An asymmetric allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines catalyzed by planarly chiral ligand/palladium-catalyst was developed in good yield with excellent a-regioselectivity （a/γ up to 30 ： 1） and moderate enantioselectivity （up to 70% ee）.

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Bibliographic Details
Published in:Chinese journal of chemistry 2012-11, Vol.30 (11), p.2641-2646
Main Author: 王炎 张涛 刘利 王东 陈拥军
Format: Article
Language:English
Subjects:
Ligands
R&D
Research & development
区域选择性
对映体选择性
手性配体
烯丙基
胺化
芳香胺
醋酸盐
钯催化剂
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Description
Summary:An asymmetric allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines catalyzed by planarly chiral ligand/palladium-catalyst was developed in good yield with excellent a-regioselectivity （a/γ up to 30 ： 1） and moderate enantioselectivity （up to 70% ee）.
ISSN:1001-604X
1614-7065