A clinical study on regional lymphatic chemotherapy using an activated carbon nanoparticle–epirubicin in patients with breast cancer

The purpose of this study was to understand the short-term therapeutic effects of an activated carbon nanoparticle–epirubicin suspension for regional lymphatic chemotherapy in patients with breast cancer. One hundred and twenty patients with stage I, II, or III primary breast cancer were randomly di...

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Bibliographic Details
Published in:Tumor biology 2012-12, Vol.33 (6), p.2341-2348
Main Authors: Yang, Qian, Wang, Xiao-dong, Chen, Jie, Tian, Chun-xiang, Li, Hong-jiang, Chen, Yu-juan, Lv, Qing
Format: Article
Language:English
Subjects:
Adult
Aged
Antibiotics, Antineoplastic - therapeutic use
Apoptosis - drug effects
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cancer Research
Carcinoma, Ductal, Breast - drug therapy
Carcinoma, Ductal, Breast - secondary
Charcoal
Chemotherapy
Drug delivery systems
Epirubicin - therapeutic use
Female
Humans
Injections, Intralymphatic
Lymph Nodes - drug effects
Lymph Nodes - pathology
Lymphatic Metastasis
Lymphatic system
Metastasis
Middle Aged
Nanoparticles
Neoplasm Staging
Prognosis
Research Article
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Summary:The purpose of this study was to understand the short-term therapeutic effects of an activated carbon nanoparticle–epirubicin suspension for regional lymphatic chemotherapy in patients with breast cancer. One hundred and twenty patients with stage I, II, or III primary breast cancer were randomly divided into three groups: the lymphatic chemotherapy group using the activated carbon nanoparticle–epirubicin suspension, the epirubicin control group, and the activated carbon control group. Each group of 40 patients was further divided into two subgroups with the drug injected either 24 or 48 h before surgery. The terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate–biotin nick end labeling (TUNEL) assay was used to determine cancer cell apoptotic indices in metastatic lymph nodes. The epirubicin concentration in the black-stained lymph nodes in the lymphatic chemotherapy treatment group was 4,144.64 ± 2,426.44 ng/g, which is significantly higher than in the epirubicin control group (335.87 ± 212.82 ng/g, P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-012-0496-y