Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing Furan(I)

The furan ring system possesses electron‐rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan...

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Bibliographic Details
Published in:Chinese journal of chemistry 2008-05, Vol.26 (5), p.916-922
Main Authors: CUI, Zi-Ning, HUANG, Juan, LI, Ying, LING, Yun, YANG, Xin-Ling, CHEN, Fu-Heng
Format: Article
Language:English
Subjects:
anti-tumor activity
fluorophenyl
furan
insecticidal activity
N,N′‐diacylhydrazine
N′-diacylhydrazine
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Summary:The furan ring system possesses electron‐rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5‐fluorophenyl‐2‐furoyl chloride with substituted benzoylhydrazide in anhydrous dichloromethane under reflux. The structures of the resultant compounds were confirmed by IR, 1H NMR, MS and elemental analysis. Insecticidal and anti‐tumor activities of these new compounds were evaluated.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200890168