The occurrence of priapism as a result of the use of a single dose of quetiapine/Tek doz ketiapin kullanimi sonrasi gelisen priapizm olgusu

• Published in: The Eurasian journal of medicine 2012-08, Vol.44 (2), p.122
• Main Authors: Ozkaya, Fatih, Ziypak, Tevfik, Adanur, Senol, Yucel, Atakan, Aydinoglu, Unsal
• Format: Article
• Language: English
• Subjects: Case studies; Causes of; Complications and side effects; Drug dosages; Drug therapy; Hypoxia; Insomnia; Leukemia; Priapism; Quetiapine
• ISSN: 1308-8734; 1308-8742
• DOI: 10.5152/eajm.2012.27

Priapism is a prolonged pathologic erection situation that occurs after sexual stimulation or without sexual stimulation. This condition is divided into two types, ischemic (low-flow, veno-occlusive) and non-ischemic (high-flow, arterial). A 68-year-old male patient applied to our clinic with the complaints of hardness and pain in the penis. Three days before he applied to our clinic, he was prescribed a single dose of 200 mg quetiapine by a psychiatry polyclinic for the complication of insomnia. Nearly 6 hours after the first dose of quetiapine, an involuntary erection occurred with accompanying pain in the penis. The patient waited for spontaneous detumescence without consulting a psychiatrist. After the patient had waited for 48 hours without any change, he applied to our clinic. Other etiologic factors of priapism were excluded (such as malignancy, blood dyscrasia, leukemia, and trauma). In blood gas samples obtained from the corpus cavernosum, hypoxia, hypercarbia, and acidosis were diagnosed. Ischemic priapism was supposed. We conclude that priapism can be viewed as a new possible side effect of quetiapine and that patients should be warned about this side effect. Key Words: Antipsychotic, Priapism, Quetiapine Priapizm, seksuel uyari sonrasinda ya da seksuel uyari olmaksizin uzamis patolojik ereksiyon durumudur. Genel olarak iskemik (dusuk akimli, venookluziv) ve noniskemik (yuksek akimli, arteriyel) olmak uzere ikiye ayrilir. Altmis sekiz yasinda erkek hasta, klinigimize peniste sertlik ve agri sikayetiyle basvurdu. Hastaya klinigimize basvurmadan 3 gun once uyuyama sikayeti ile gittigi psikiyatri poliklinigince ketiapin 200 mg gunde tek doz baslanmis. Ilk doz Ketiapinden yaklasik 6 saat sonra hastada istemsiz bir sekilde peniste sertlesme ve agri baslamis. Psikiyatriste danismaksizin ilaci birakip sertlesmenin kendiliginden gecmesini beklemis. Kirk sekiz saat kadar bekledikten sonra yumusama olmamasi uzerine hasta klinigimize basvurdu. Hastada Priapizme neden olabilecek diger butun etiyolojik faktorler (Malignite, kan diskrazileri, losemi, travma vb.) dislandi. Ketiapin kullanim oykusu bulunan ve korpus kavernozumdan alinan kangazi orneginde hipoksi, hiperkarbi ve asidoz tespit edilen hastada iskemik priapizm tanisi konuldu. Ketiapin kullaniminda olasi yeni bir yan etki olarak priapizm gorulebilecegini ve hastanin bu konuda uyarilmasi gerektigini hatirlatmak isteriz. Anahtar Kelimeler: Antipsikotik, Priapizm, Ketiapin