Two new lignans from the stems of Schisandra bicolor

Two new lignans, named zuihonins E (1) and F (2), were isolated from the stems of Schisandra bicolor Cheng var. tuberculata Law. The structures of the new lignans were elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR, and MS experiments, and their absolute stereochem...

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Bibliographic Details
Published in:Journal of asian natural products research 2012-12, Vol.14 (12), p.1116-1121
Main Authors: Huang, Ri-Ming, Huang, Hui-Juan, Zhang, Nen-Ling, Zhu, Yue-Hui, Jiang, Xiao-Fei, Su, Zhi-Wei, Yang, Jian-Xiang, Xu, Zhi-Fang, Li, Chuan-Rong, Qiu, Samuel X
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Biological and medical sciences
Breast cancer
breast neoplasms
Chemical constitution
chemical structure
Drug Screening Assays, Antitumor
Female
Fundamental and applied biological sciences. Psychology
Hep G2 Cells
hepatoma
Humans
lignans
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
lung neoplasms
Molecular Structure
neoplasm cells
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Plant physiology and development
Plant Stems - chemistry
Schisandra
Schisandra - chemistry
Schisandra bicolor
stems
stereochemistry
zuihonins E and F
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Summary:Two new lignans, named zuihonins E (1) and F (2), were isolated from the stems of Schisandra bicolor Cheng var. tuberculata Law. The structures of the new lignans were elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR, and MS experiments, and their absolute stereochemistry was determined by circular dichroism spectrum. Compounds 1 and 2 did not inhibit the growth of hepatoma carcinoma cell (HepG2), lung carcinoma cell (A549), and human breast carcinoma (MCF-7) cell lines.
ISSN:1477-2213
1028-6020
1477-2213
DOI:10.1080/10286020.2012.725394