Synthesis of highly functionalized thiophenes by three-component and one-pot reaction

Reaction between ethyl 2-cyano-3-arylacrylate and dialkyl acetylenedicarboxylates in the presence of KSCN at room temperature provided a simple and efficient one-pot route for the synthesis of highly functionalized thiophenes. The reaction is characterized by mild conditions, short reaction time and...

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Bibliographic Details
Published in:Journal of sulfur chemistry 2012-06, Vol.33 (3), p.273-277
Main Authors: Hassanabadi, Alireza, Hosseini-Tabatabaei, Mohammad R.
Format: Article
Language:English
Subjects:
anionic nucleophile
dialkyl acetylenedicarboxylate
ethyl 2-cyano-3-arylacrylate
highly functionalized thiophene
three-component reaction
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Summary:Reaction between ethyl 2-cyano-3-arylacrylate and dialkyl acetylenedicarboxylates in the presence of KSCN at room temperature provided a simple and efficient one-pot route for the synthesis of highly functionalized thiophenes. The reaction is characterized by mild conditions, short reaction time and tolerance to various functional groups.
ISSN:1741-5993
1741-6000
DOI:10.1080/17415993.2012.662981