Evaluation and comparison of human absorbed dose of 90 Y-DOTA-Cetuximab in various age groups based on distribution data in rats

The organ radiation-absorbed doses have been evaluated for humans in six age groups and both genders based on animal data. After intravenous administration of 90 Y-DOTA-Cetuximab to five groups of rats, they were sacrificed at exact time intervals (2, 24, 48, 72, and 96 h) and the percentage of inje...

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Bibliographic Details
Published in:Journal of medical physics 2012-10, Vol.37 (4), p.226
Main Authors: Vakili, Ariandokht, Jalilian, Amir, Moghadam, Alireza, Ghazi-Zahedi, Maryam, Salimi, Bahram
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Comparative analysis
Epidermal growth factor
Nuclear radiation
Rodents
Tomography
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Summary:The organ radiation-absorbed doses have been evaluated for humans in six age groups and both genders based on animal data. After intravenous administration of 90 Y-DOTA-Cetuximab to five groups of rats, they were sacrificed at exact time intervals (2, 24, 48, 72, and 96 h) and the percentage of injected dose per gram of each organ was calculated by direct counting from rat data. By using the formulation that Medical Internal Radiation Dose suggests, radiation-absorbed doses for all organs were calculated and extrapolated from rat to human. The total body absorbed dose for all groups was >22 mGy due to pure β-emission of the applied radiopharmaceutical. The effective dose resulting from an intravenously injected activity of 100 MBq is 56.7 mSv for a 60-kg female adult and 60.3 mSv for a 73-kg male adult. The results demonstrated the usefulness of this method for estimation of β-absorbed dose in humans.
ISSN:0971-6203
1998-3913
DOI:10.4103/0971-6203.103609