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Evaluation of microvascular density in Barrett’s associated neoplasia
Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. The aim of this study is to assess the correlation between microvascular density and disease pro...
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| Published in: | Modern pathology 2013, Vol.26 (1), p.125-130 |
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| container_title | Modern pathology |
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| creator | Konda, Vani J A Hart, John Lin, Shang Tretiakova, Maria Gordon, Ilyssa O Campbell, Lucas Kulkarni, Anirudh Bissonnette, Marc Seewald, Stefan Waxman, Irving |
| description | Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. The aim of this study is to assess the correlation between microvascular density and disease progression of non-dysplastic Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and invasive carcinoma in the superficial aspects of the tissue. Archival histological specimens from two referral centers for Barrett’s esophagus and esophageal cancer were selected for review. A total of 160 regions marked according to histological grade were assessed with digitally interactive software to measure microvascular density. This was quantified in three levels: 0–50, 50–100 and 100–150
μ
m. In the areas of gastric cardia, Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (
P |
| doi_str_mv | 10.1038/modpathol.2012.146 |
| format | article |
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μ
m. In the areas of gastric cardia, Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (
P
<0.0001) among the five groups in the most superficial 150
μ
m of the mucosa. Furthermore, when examining the pairwise difference between the groups, there was a significant difference between cancer and each of the lower grades of histology (
P
<0.05) and between high-grade dysplasia and each of the lower grades of histology (
P
<0.05). These statistically significant differences were preserved in examining the depth at the most superficial 50
μ
m. We have used digital pathology to demonstrate a significant and stepwise increase in microvascular density, which supports the hypothesis that angiogenesis has a key role in Barrett’s carcinogenesis. Furthermore, the differences in the most superficial mucosal layers are consistent with findings of increased vascularity by depth-restricted imaging modalities.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2012.146</identifier><identifier>PMID: 22918163</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/67/2328 ; 692/699/1503/1476/1322 ; 692/699/67/1504/1477 ; Angiogenesis ; Automation ; Barrett Esophagus - pathology ; Carcinoma - blood supply ; Carcinoma - pathology ; Disease Progression ; Endoscopy ; Esophageal cancer ; Esophageal Neoplasms - blood supply ; Esophageal Neoplasms - pathology ; Gastroenterology ; Histology ; Humans ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Microvessels - pathology ; Neovascularization, Pathologic - pathology ; original-article ; Pathology ; Precancerous Conditions - blood supply ; Precancerous Conditions - pathology ; Software</subject><ispartof>Modern pathology, 2013, Vol.26 (1), p.125-130</ispartof><rights>United States and Canadian Academy of Pathology, Inc. 2013</rights><rights>Copyright Nature Publishing Group Jan 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-63f74aa229082215c7d435330cf2111ddf43c95ef1385b78eb23b718d8cf4e163</citedby><cites>FETCH-LOGICAL-c485t-63f74aa229082215c7d435330cf2111ddf43c95ef1385b78eb23b718d8cf4e163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22918163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konda, Vani J A</creatorcontrib><creatorcontrib>Hart, John</creatorcontrib><creatorcontrib>Lin, Shang</creatorcontrib><creatorcontrib>Tretiakova, Maria</creatorcontrib><creatorcontrib>Gordon, Ilyssa O</creatorcontrib><creatorcontrib>Campbell, Lucas</creatorcontrib><creatorcontrib>Kulkarni, Anirudh</creatorcontrib><creatorcontrib>Bissonnette, Marc</creatorcontrib><creatorcontrib>Seewald, Stefan</creatorcontrib><creatorcontrib>Waxman, Irving</creatorcontrib><title>Evaluation of microvascular density in Barrett’s associated neoplasia</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. The aim of this study is to assess the correlation between microvascular density and disease progression of non-dysplastic Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and invasive carcinoma in the superficial aspects of the tissue. Archival histological specimens from two referral centers for Barrett’s esophagus and esophageal cancer were selected for review. A total of 160 regions marked according to histological grade were assessed with digitally interactive software to measure microvascular density. This was quantified in three levels: 0–50, 50–100 and 100–150
μ
m. In the areas of gastric cardia, Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (
P
<0.0001) among the five groups in the most superficial 150
μ
m of the mucosa. Furthermore, when examining the pairwise difference between the groups, there was a significant difference between cancer and each of the lower grades of histology (
P
<0.05) and between high-grade dysplasia and each of the lower grades of histology (
P
<0.05). These statistically significant differences were preserved in examining the depth at the most superficial 50
μ
m. We have used digital pathology to demonstrate a significant and stepwise increase in microvascular density, which supports the hypothesis that angiogenesis has a key role in Barrett’s carcinogenesis. Furthermore, the differences in the most superficial mucosal layers are consistent with findings of increased vascularity by depth-restricted imaging modalities.</description><subject>631/67/2328</subject><subject>692/699/1503/1476/1322</subject><subject>692/699/67/1504/1477</subject><subject>Angiogenesis</subject><subject>Automation</subject><subject>Barrett Esophagus - pathology</subject><subject>Carcinoma - blood supply</subject><subject>Carcinoma - pathology</subject><subject>Disease Progression</subject><subject>Endoscopy</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - blood supply</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Gastroenterology</subject><subject>Histology</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvessels - pathology</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>original-article</subject><subject>Pathology</subject><subject>Precancerous Conditions - 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The aim of this study is to assess the correlation between microvascular density and disease progression of non-dysplastic Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and invasive carcinoma in the superficial aspects of the tissue. Archival histological specimens from two referral centers for Barrett’s esophagus and esophageal cancer were selected for review. A total of 160 regions marked according to histological grade were assessed with digitally interactive software to measure microvascular density. This was quantified in three levels: 0–50, 50–100 and 100–150
μ
m. In the areas of gastric cardia, Barrett’s esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (
P
<0.0001) among the five groups in the most superficial 150
μ
m of the mucosa. Furthermore, when examining the pairwise difference between the groups, there was a significant difference between cancer and each of the lower grades of histology (
P
<0.05) and between high-grade dysplasia and each of the lower grades of histology (
P
<0.05). These statistically significant differences were preserved in examining the depth at the most superficial 50
μ
m. We have used digital pathology to demonstrate a significant and stepwise increase in microvascular density, which supports the hypothesis that angiogenesis has a key role in Barrett’s carcinogenesis. Furthermore, the differences in the most superficial mucosal layers are consistent with findings of increased vascularity by depth-restricted imaging modalities.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>22918163</pmid><doi>10.1038/modpathol.2012.146</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/2328 692/699/1503/1476/1322 692/699/67/1504/1477 Angiogenesis Automation Barrett Esophagus - pathology Carcinoma - blood supply Carcinoma - pathology Disease Progression Endoscopy Esophageal cancer Esophageal Neoplasms - blood supply Esophageal Neoplasms - pathology Gastroenterology Histology Humans Laboratory Medicine Medicine Medicine & Public Health Microvessels - pathology Neovascularization, Pathologic - pathology original-article Pathology Precancerous Conditions - blood supply Precancerous Conditions - pathology Software |
| title | Evaluation of microvascular density in Barrett’s associated neoplasia |
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