Poly-[gamma]-d-Glutamic Acid Capsule Interferes with Lytic Infection of Bacillus anthracis by B. anthracis-Specific Bacteriophages

The poly-γ-d-glutamic acid capsule of Bacillus anthracis is a barrier to infection by B. anthracis-specific bacteriophages. Capsule expression was found to completely inhibit lytic infection by γ phage, an observation supported by the demonstration that this phage does not elaborate a hydrolase that...

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Bibliographic Details
Published in:Applied and environmental microbiology 2013-01, Vol.79 (2), p.714
Main Authors: Negus, David, Burton, Jane, Sweed, Angela, Gryko, Romuald, Taylor, Peter W
Format: Article
Language:English
Subjects:
Bacteria
Gene expression
Infections
Microbiology
Online Access:Get full text
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Summary:The poly-γ-d-glutamic acid capsule of Bacillus anthracis is a barrier to infection by B. anthracis-specific bacteriophages. Capsule expression was found to completely inhibit lytic infection by γ phage, an observation supported by the demonstration that this phage does not elaborate a hydrolase that would facilitate penetration through the protective capsule outer layer. [PUBLICATION ABSTRACT]
ISSN:0099-2240
1098-5336