Anti-cyclic citrullinated peptide frequency in patients with chronic hepatitis C virus infection and effect of presence of systemic disease/Kronik hepatit C virus enfeksiyonlu hastalarda anti-siklik sitrullenmis peptid sikligi ve sistemik hastalik varliginin etkisi

Objective: Patients with chronic hepatitis C virus (HCV) infection may show a variety of rheumatic symptoms and signs. Anti-cyclic citrullinated peptide (anti-CCP) is widely used as a marker, particularly for rheumatoid arthritis (RA), and may be positive in some diseases that also cause arthritis,...

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Bibliographic Details
Published in:The Eurasian journal of medicine 2012-12, Vol.44 (3), p.131
Main Authors: Albayrak, Ayse, Dursun, Hakan, Uyanik, Muhammet Hamidullah, Cerrah, Serkan
Format: Article
Language:English
Subjects:
Biological markers
Care and treatment
Complications and side effects
Development and progression
Diagnosis
Disease
Enzyme-linked immunosorbent assay
Health aspects
Hepatitis
Hepatitis C
Hepatitis C virus
Infections
Liver cirrhosis
Physiological aspects
Rheumatoid arthritis
Risk factors
Studies
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Summary:Objective: Patients with chronic hepatitis C virus (HCV) infection may show a variety of rheumatic symptoms and signs. Anti-cyclic citrullinated peptide (anti-CCP) is widely used as a marker, particularly for rheumatoid arthritis (RA), and may be positive in some diseases that also cause arthritis, such as systemic lupus erythematosus, familial Mediterranean fever, Behcet's disease, and psoriatic arthritis. Materials and Methods: Blood samples were obtained (in routine protocols) from 57 patients with chronic HCV infection from the Gastroenterology Clinic of Ataturk University and Infectious Disease Clinic of Erzurum Region Research and Education Hospital. Normal sera were obtained from volunteer blood donors at Ataturk University. Results: Anti-CCP antibodies were found in 5 chronic HCV patients with RA. The patient with the highest anti-CCP antibody level had RA. No patient in the control group was positive for anti-CCP antibodies. Conclusion: Anti-cyclic citrullinated peptide (anti-CCP) antibodies should be measured frequently in patients with HCV and an additional systemic disease, such as end-stage chronic renal failure, chronic obstructive airway disease, and decompensated liver cirrhosis, to differentiate RA from non-RA arthropathy. Key Words: Anti-CCP, Chronic hepatitis C virus, Rheumatoid arthritis Amac: Kronik hepatit C virus (HCV) enfeksiyonu cesitli romatolojik belirti ve semptomlarla seyredebilir. Anti-siklik sitrullenmis peptid (Anti-CCP) ozellikle romatoid artrit (RA) tanisinda yaygin sekilde kullanilan, ayrica sistemik lupus eritematozus, ailevi akdeniz atesi ve psoriatik artrit gibi artritle birlikte seyreden bazi hastaliklarda da pozitif oldugu gosterilmis bir antikordur. Gerec ve Yontem: Calismada Ataturk Universitesi Gastroenteroloji Klinigi ve Erzurum Bolge Egitim ve Arastirma Hastanesi Enfeksiyon Hastaliklari Klinigi'nden 57 kronik HCV enfeksiyonlu hastadan rutin tetkikleri sirasinda alinmis olan kanlar kullanildi. Kontrol kanlari Ataturk Universitesi kan vericilerinden artan kanlardan toplandi. Bulgular: Kronik HCV enfeksiyonuna ilaveten RA tanisi da almis olan 5 hastanin tamaminda Anti-CCP pozitif bulundu. Anti-CCP seviyesi en yuksek olan hasta da RA'i olan bir hasta idi. Kontrol grubundaki hastalardan hicbirinde Anti-CCP pozitif degildi. Sonuc: Kronik HCV'li hastalarda kronik bobrek yetmezligi, kronik obstriktifakciger hastaligi veya dekompanse karaciger sirozu gibi sistemik hastaliklarin varliginda, Anti-CCP daha sik olarak gorule
ISSN:1308-8734
1308-8742
DOI:10.5152/eajm.2012.31