Helicobacter pylori infections in chronic obstructive pulmonary disease/Kronik obstruktif akciger hastaliginda helicobacter pylori enfeksiyonu

• Published in: The Eurasian journal of medicine 2012-12, Vol.44 (3), p.144
• Main Authors: Tabaru, Ali, Gorguner, Metin, Akgun, Metin, Meral, Mehmet, Sahin, Ali
• Format: Article
• Language: English
• Subjects: Breath tests; Chronic obstructive pulmonary disease; Diagnosis; Disease; Drug therapy; Health aspects; Helicobacter pylori; Immunoglobulin G; Infections; Lung diseases, Obstructive; Physiological aspects; Prevalence studies (Epidemiology); Risk factors; Studies; Ulcers
• ISSN: 1308-8734; 1308-8742
• DOI: 10.5152/eajm.2012.34

Objective: We aimed to investigate the prevalence of Helicobacter pylori (H. pylori) in patients with chronic obstructive pulmonary disease (COPD) using the C-14 urea-breath test (C14UBT) and to determine whether there is an association between H. pylori infection and the severity of COPD. This is the first report in the literature of the use of C14UBT to investigate the prevalence of H. pylori in patients with COPD. Materials and Methods: Fifty subjects with COPD (38 males and 12 females, aged 61[+ or -]10 years) and 20 control subjects (10 males and 10 females, aged 55[+ or -]11 years) were evaluated. C14UBT was used to determine H. pylori infection. Results: The prevalences of H. pylori infection in subjects with COPD and in controls were 72% and 65%, respectively (p = 0.56). Forced expiratory volume in one second ([FEV.sub.1]) and forced vital capacity (FVC) values were significantly higher in the H. pylori-infected subjects with COPD than in the uninfected subjects (p = 0.008 and p = 0.006, respectively). Conclusion: The presence of H. pylori infection in COPD patients affects pulmonary functions, but the effects of H. pylori infection on the respiratory system and COPD are not clear. Key Words: COPD, Helicobacter pylori, Infection, Lung Amac: Bu calismada kronik obstruktif akciger hastaligi (KOAH) bulunan hastalarda C-14 ure-nefes testi (C14UNT) kullanarak Helicobacter pylori (H. pylori) prevalansini ve H. pylori enfeksiyonu ile KOAH siddeti arasinda bir iliski olup olmadigini arastirmayi hedefledik. Bu, KOAH hastalarinda H. pylori prevalansini araitirmak icin C14UNT'nin kullanildigi literaturdeki ilk calismadir. Gerec ve Yontem: KOAH'li 50 olgu (38 erkek ve 12 kadin, ortalama yas: 61[+ or -]10 yil) ve 20 saglikli kontrol (10 erkek ve 10 kadin, ortalama yas: 55[+ or -]11 yil) incelendi. H. pylori enfeksiyonunu saptamak icin C14UBT kullanildi. Bulgular: KOAH olgulari ve kontroller icin H. pylori enfeksiyonu prevalansi sirasiyla, %72 ve %65 olarak belirlendi (p = 0.56). H. pylori enfeksiyonu bulunan KOAH olgularinda, birinci saniyedeki zorlu ekspiratuvar volum ([FEV.sub.1]) ve zorlu vital kapasite (FVC) degerleri, enfeksiyon bulunmayanlardan anlamli olarak daha yuksek bulundu (sirasiyla, p = 0.008 ve p = 0.006). Sonuc: KOAH hastalarinda H. pylori enfeksiyonu varligi solunum fonksiyonlarini etkilemektedir, fakat H. pylori enfeksiyonunun solunum sistemi ve KOAH uzerine etkileri tam olarak aydinlatilmamistir. Anahtar Kelimeler: KOAH, Helicobacter pylori,