Amelioration of radiation-induced acute inflammation and mucosal atrophy by beta-hydroxy-beta-methylbutyrate, l-glutamıne, and l-argınıne: results of an experimental study

Purpose We aimed to evaluate the effects of β-hydroxy-β-methylbutyrate, l -glutamine, and l -arginine (HMB/Glu/Arg) on radiation-induced acute inflammation and mucosal atrophy in the oral mucosa. Methods Twenty-eight rats were divided into four groups. group (G) 1 was defined as control group, and G...

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Bibliographic Details
Published in:Supportive care in cancer 2013-03, Vol.21 (3), p.883-888
Main Authors: Yavas, Cagdas, Yavas, Guler, Acar, Hilal, Toy, Hatice, Yuce, Deniz, Akyurek, Serap, Ata, Ozlem
Format: Article
Language:English
Subjects:
Acute Disease
Administration, Oral
Amino acids
Analysis
Animals
Arginine
Arginine - administration & dosage
Arginine - pharmacology
Atrophy
Dietary supplements
Drug Combinations
Female
Glutamine
Glutamine - administration & dosage
Glutamine - pharmacology
Inflammation
Inflammation - drug therapy
Inflammation - etiology
Medicine
Medicine & Public Health
Mouth
Mouth Mucosa - drug effects
Mouth Mucosa - pathology
Nuclear radiation
Nursing
Nursing Research
Oncology
Original Article
Pain Medicine
Radiation Injuries, Experimental - drug therapy
Radiation Injuries, Experimental - pathology
Radiation therapy
Radiotherapy
Rats
Rats, Wistar
Rehabilitation Medicine
Rodents
Side effects
Valerates - administration & dosage
Valerates - pharmacology
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Summary:Purpose We aimed to evaluate the effects of β-hydroxy-β-methylbutyrate, l -glutamine, and l -arginine (HMB/Glu/Arg) on radiation-induced acute inflammation and mucosal atrophy in the oral mucosa. Methods Twenty-eight rats were divided into four groups. group (G) 1 was defined as control group, and G2 was the radiation therapy (RT) group. G3 and G4 were HMB/Glu/Arg control and 17 Gy RT plus HMB/Glu/Arg groups, respectively. A single dose of 17 Gy RT was given to the head and neck area, and the active supplement consisting of 5.2 g of HMB, 29.6 g arginine, and 29.6 g of glutamine which was equivalent to 60 kg adult dose was calculated for each rat and administrated orally. HMB/Glu/Arg started from the day of RT and continued until the animals were sacrificed 7 days after the RT. The extent of acute inflammation and mucosal atrophy for each rat was quantified with image analysis of histological sections of the oral mucosa. Results There were significant differences in terms of epithelial thickness, subepithelial edema, inflammation, and congestion between all groups ( p values were
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-012-1601-x