Xymedon restores T-cell immune response inhibited by [gamma]-irradiationin vivo: Interrelations with Ca2+-ATPase and DNA-relaxing activities

High radioprotective activity of xymedon was shown in mice. Radioprotective effects of this preparation were accompanied by restoration of the delayed-type hypersensitivity response and Ca^sup 2+^-ATPase activity in splenocytes which were inhibited by γ-irradiation (3 Gy). At concentrations of 10^su...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-01, Vol.127 (1), p.59
Main Authors: Cherepnev, G V, Slabnov, Yu D, Tsibul'kin, A P, Karimova, F G, Garaev, R S
Format: Article
Language:English
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Summary:High radioprotective activity of xymedon was shown in mice. Radioprotective effects of this preparation were accompanied by restoration of the delayed-type hypersensitivity response and Ca^sup 2+^-ATPase activity in splenocytes which were inhibited by γ-irradiation (3 Gy). At concentrations of 10^sup -3^ and 10^sup -6^ M xymedon stimulated the activity of DNA topoisomerase-I of splenocyte nuclei. Here we discuss a mechanism of radioprotective effects of pyrimidine derivatives associated with the inhibition of apoptosis of lymphoid cells and the stimulation of proliferation and differentiation of lymphoid precursor cells.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02432802