The number of functioning hemopoietic clones in transplantation-restored bone marrow of mice depends on the dose of transplanted cells

The clone composition of mouse bone marrow restored by transplantations of different doses of hemopoietic cells containing the unique genetic markers at the expense of integration of human adenosine deaminase gene is analyzed. Low dose of donor hemopoietic cells accelerates reversion of hemopoiesis...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1997-07, Vol.124 (1), p.696-698
Main Authors: Drize, N. I., Todriya, T. V., Chertkov, I. L.
Format: Article
Language:English
Subjects:
Bone marrow
Transplants & implants
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Summary:The clone composition of mouse bone marrow restored by transplantations of different doses of hemopoietic cells containing the unique genetic markers at the expense of integration of human adenosine deaminase gene is analyzed. Low dose of donor hemopoietic cells accelerates reversion of hemopoiesis to the recipient type and decreases the number of functioning clones. This finding confirms that a stem hemopoietic cell cannot maintain itself and its proliferative potential is limited. For long and stable repopulation of the recipient subjected to gene therapy, the maximum possible number of transduced stem hemopoietic cells should be transplanted.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445065