Interaction of bis-[beta]-chlorethylamine estrogen derivatives with human ovarian adenocarcinoma cells

Antiproliferative effect of bis-β-chlorethylamine estrogen derivatives on human ovarian adenocarcinoma CaOV cells depends on the dose of the drug. In concentrations of 10^sup -5^ and 5×10^sup -6^ M they inhibit, while in a dose of 5×10^sup -7^ M stimulate cell proliferation. It is assumed that CaOV...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-03, Vol.127 (3), p.272
Main Authors: Semeikin, A V, Rzheznikov, V M, Minailova, O N, Dobrynin, Ya V, Mayatskaya, E E
Format: Article
Language:English
Subjects:
Binding sites
Estrogens
Medical research
Online Access:Get full text
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Summary:Antiproliferative effect of bis-β-chlorethylamine estrogen derivatives on human ovarian adenocarcinoma CaOV cells depends on the dose of the drug. In concentrations of 10^sup -5^ and 5×10^sup -6^ M they inhibit, while in a dose of 5×10^sup -7^ M stimulate cell proliferation. It is assumed that CaOV cells express estradiol receptors. The interaction of these cytostatics with estrogen-binding sites on CaOV cells is demonstrated.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433354