Interactions between natural autoantibodies to tumor-associated human ovarian cancer antigen and murine ovarian cancer cells CaO-1

The interactions between tumor cells and autoantibodies to tumor-associated human ovarian cancer antigen isolated from the plasma of a non-cancer patient are demonstrated using an original model of pseudomucinous murine ovarian carcinoma CaO-1. The use of natural auto-antibodies for active immunothe...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-02, Vol.127 (2), p.206-208
Main Authors: Amandzholov, B. S., Lebedin, Yu. S., Chukanov, S. V., Toptygin, A. Yu, Sitdikova, S. M., Moroz, L. L., Manyuk, L. V., Donenko, F. V.
Format: Article
Language:English
Subjects:
Medical research
Ovarian cancer
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Summary:The interactions between tumor cells and autoantibodies to tumor-associated human ovarian cancer antigen isolated from the plasma of a non-cancer patient are demonstrated using an original model of pseudomucinous murine ovarian carcinoma CaO-1. The use of natural auto-antibodies for active immunotherapy of tumors may be more effective and safe than murine monoclonal antibodies to CA 125, because there will be no reaction to a foreign protein.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433117