Effect of pyrimidine derivatives on adenylate cyclase system of immunocompetent cell regulationin vitro

The pyrimidine derivatives xymedone and diucifon decrease the activity of adenylate cyclase, as shown in experiments on thymocytes and lymphocytes of guinea pig lymph nodes and human peripheral blood lymphocytes. Inhibition of the enzyme depends on the subpopulation and species appurtenance of immun...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1998-06, Vol.125 (6), p.588-590
Main Authors: Slabnov, Yu. D., Cherepnev, G. V., Karimova, F. G., Garaev, R. S.
Format: Article
Language:English
Subjects:
Derivatives
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Summary:The pyrimidine derivatives xymedone and diucifon decrease the activity of adenylate cyclase, as shown in experiments on thymocytes and lymphocytes of guinea pig lymph nodes and human peripheral blood lymphocytes. Inhibition of the enzyme depends on the subpopulation and species appurtenance of immunocompetent cells. The relationship between the results and effects of pyrimidine derivatives in experiment and clinical setting is discussed.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445248