Mitochondrial components in the mechanism of antihypoxic effects of baikal scullcap extract

Antioxidant properties of baikalin, a flavonoid from baikal scullcap (Scutellaria baikalensis Georgi), depend on its ability to scavenge free radicals. In contrast to standard antioxidant ionol (butylated hydroxytoluene) baikal scullcap extract and baikalin possess cerebroprotective activity and sta...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-09, Vol.128 (3), p.942-944
Main Authors: Khazanov, V. A., Saifutdinov, R. R.
Format: Article
Language:English
Subjects:
Free radicals
Rodents
Online Access:Get full text
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Summary:Antioxidant properties of baikalin, a flavonoid from baikal scullcap (Scutellaria baikalensis Georgi), depend on its ability to scavenge free radicals. In contrast to standard antioxidant ionol (butylated hydroxytoluene) baikal scullcap extract and baikalin possess cerebroprotective activity and stabilize energy metabolism in rat brain during hypoxia. Pharmacological effect of the extract is determined by the presence of a falvonoid. It is suggested that antihypoxic effect of baikalin depends on its ability to interact with mitochondrial NADH dehydrogenase.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02438092