Serotonin-induced platelet aggregation and release of3H-serotonin in patients with migraine

Serotonin-induced platelet aggregation in patients with migraine without aoura is less pronounced than in healthy individuals. In 50% of the patients the platelet serotonin transport system is characterized by increased sensitivity to serotonin: serotonin induced a more potent (by 26%) release of^su...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1998-08, Vol.126 (2), p.780-782
Main Authors: Pukhal'skaya, T. G., Kolosova, O. A., Men'shikov, M. Yu
Format: Article
Language:English
Subjects:
Drug therapy
Migraine
Serotonin
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Summary:Serotonin-induced platelet aggregation in patients with migraine without aoura is less pronounced than in healthy individuals. In 50% of the patients the platelet serotonin transport system is characterized by increased sensitivity to serotonin: serotonin induced a more potent (by 26%) release of^sup 3^H-serotonin from platelets, while the serotonin transport inhibitor imipramine blocked this effect. Thus, the serotonin transport system in patients with migraine differs from that of healthy indiduals.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02446908