Enhanced expression of sarcoplasmic reticulum Ca2+-ATPase gene plays a role in protective effects of nitric oxide

This study verifies the hypothesis that NO-dependent regulation of sarcoplasmic reticulum Ca^sup 2+^-ATPase gene (SERCA) plays an important role in preventing Ca^sup 2+^ overload after exposure to damaging factors. The data confirmed NO-dependent activation of SERCA expression and important role of...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-10, Vol.128 (4), p.981-984
Main Authors: Aimasheva, N. P., Malenyuk, E. B., Manukhina, E. B., Khaspekov, G. L., Mikoyan, V. D., Kubrina, L. N., Vanin, A. F., Malyshev, I. Yu
Format: Article
Language:English
Subjects:
Calcium
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Summary:This study verifies the hypothesis that NO-dependent regulation of sarcoplasmic reticulum Ca^sup 2+^-ATPase gene (SERCA) plays an important role in preventing Ca^sup 2+^ overload after exposure to damaging factors. The data confirmed NO-dependent activation of SERCA expression and important role of this mechanism in the reduction of calcium overload.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433183