Some mechanisms of antiarrhythmic effect of phosphoenolpyruvate

Depolarization automaticity was modeled on the papillary muscle from the guinea pig heart. Phosphoenolpyruvate (0.1 mM) 2-fold decreased the high-frequency calcium-dependent automaticity, but only weakly affected frequency of action potentials, whose upstroke was formed by fast sodium current or had...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-10, Vol.128 (4), p.1015-1017
Main Authors: Balashov, V. P., Sosunov, E. A., Balykova, L. A., Sernov, L. N.
Format: Article
Language:English
Subjects:
Rodents
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Summary:Depolarization automaticity was modeled on the papillary muscle from the guinea pig heart. Phosphoenolpyruvate (0.1 mM) 2-fold decreased the high-frequency calcium-dependent automaticity, but only weakly affected frequency of action potentials, whose upstroke was formed by fast sodium current or had a mixed nature. Phosphoenolpyruvate shifted the diastolic potential toward negative values, which depended on the amplitude of depolarization step. These effects developed 10-15 min after application of the preparation.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433193