Role of interferon-[gamma] in regulation of antiproliferative activity of bone marrow nonadherent cells

Bone marrow nonadherent cells were cultured for 3 days with supernatants of concanavalin A-stimulated splenocytes containing interferon-γ, whose activity was estimated by the ability to induced NO production. Supernatants with a high inducing activity decreased natural suppressor activity of bone ma...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-12, Vol.128 (6), p.1248
Main Authors: Bel'skii, Yu P, Danilets, M G, Bel'skaya, N V, Stal'bovskaya, E S, Kusmartsev, S A
Format: Article
Language:English
Subjects:
Bone marrow
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Summary:Bone marrow nonadherent cells were cultured for 3 days with supernatants of concanavalin A-stimulated splenocytes containing interferon-γ, whose activity was estimated by the ability to induced NO production. Supernatants with a high inducing activity decreased natural suppressor activity of bone marrow nonadherent cells and production of NO, but the activity of the supernatant of these cells increased. Inhibition of NO production during treatment with these supernatants prevented the decrease in suppressor activity; production of NO then increased. Supernatants with a low inducing activity increased natural suppressor activity of bone marrow nonadherent cells but not NO production.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02434831