Cardiotropic effects of met-enkephalin and somatostatin under conditions of neurotensin receptor blockade

Pretreatment with the neurotensin receptor antagonist decreased the severity and time of Metenkephalin-induced inhibition of vagal chronotropic effects in cats. The opiate receptor antagonist naloxone produced a delayed inhibitory effect on the synchronizing component of the vagal chronotropic effec...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-11, Vol.130 (5), p.1038-1040
Main Authors: Osadchii, O. E., Totskaya, E. K., Pokrovskii, V. M., Kurzanov, A. N.
Format: Article
Language:English
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Summary:Pretreatment with the neurotensin receptor antagonist decreased the severity and time of Metenkephalin-induced inhibition of vagal chronotropic effects in cats. The opiate receptor antagonist naloxone produced a delayed inhibitory effect on the synchronizing component of the vagal chronotropic effect under conditions of neurotensin receptor blockade. Cardiotropic effects of somatostatin remained unchanged during neurotensin receptor blockade. These data indicate one-way and two-way interactions between peptides modulating parasympathetic cardiac regulation.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02688172