MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma

Gallbladder cancer is an aggressive cancer with extremely poor prognosis. Over 90% of patients are diagnosed at an advanced, inoperable stage with metastasis and invasion to other organs. In this study, the expression of metadherin (MTDH) and erythropoietin‐producing hepatoma‐amplified sequence (Eph...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic cytopathology 2013-03, Vol.41 (3), p.199-205
Main Authors: Liu, Dong-Cai, Yang, Zhu-Lin
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adult
Aged
Biomarkers, Tumor - metabolism
Cell Adhesion Molecules - metabolism
China - epidemiology
chronic cholecystitis
EphA7
Female
gallbladder cancer
Gallbladder Neoplasms - metabolism
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - pathology
gallbladder polyp
Humans
Immunohistochemistry - methods
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Middle Aged
MTDH
Neoplasm Invasiveness
Prognosis
Receptor, EphA7 - metabolism
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gallbladder cancer is an aggressive cancer with extremely poor prognosis. Over 90% of patients are diagnosed at an advanced, inoperable stage with metastasis and invasion to other organs. In this study, the expression of metadherin (MTDH) and erythropoietin‐producing hepatoma‐amplified sequence (Eph) receptor A7 (EphA7) in 96 benign and 108 malignant lesions of gallbladder was determined by immunohistochemistry, and their correlations with pathological features and prognosis were analyzed. Positive expression of EphA7 and MTDH was significantly higher in gallbladder adenocarcinoma than in benign lesions. In adenocarcinoma, the positive expression of EphA7 and MTDH was significantly associated with differentiation, tumor mass, lymphnode metastasis, invasion, and overall survival. Multivariate Cox regression analysis suggested that positive expression of EphA7 and MTDH was an independent poor‐prognostic predictor in gallbladder adenocarcinoma. The elevated expression of EphA7 and/or MTDH is closely related to carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.21821