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"Intermediate-risk-" und "High-risk-Prostatakarzinompatienten"

Wir haben die Häufigkeit von Lymphknotenmetastasen bei ausgedehnter pelviner Lymphadenektomie (ePLND) ausgewertet. Der radikalen Prostatektomie und ePLND unterzogen sich 174 Patienten mit "Intermediate-" und "High-risk-Prostatakarzinom". Ausgewertet wurden Zahl der entfernten Lym...

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Published in:Urologe. Ausgabe A 2013-02, Vol.52 (2), p.240
Main Authors: Osmonov, Dk, Boller, A, Aksenov, A, Naumann, M, Jünemann, Kp
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Boller, A
Aksenov, A
Naumann, M
Jünemann, Kp
description Wir haben die Häufigkeit von Lymphknotenmetastasen bei ausgedehnter pelviner Lymphadenektomie (ePLND) ausgewertet. Der radikalen Prostatektomie und ePLND unterzogen sich 174 Patienten mit "Intermediate-" und "High-risk-Prostatakarzinom". Ausgewertet wurden Zahl der entfernten Lymphknoten (LK) sowie Zahl und Lage der Metastasen. In der Gruppe 1 ("intermediate risk"; n=115) wurden durchschnittlich 20,5 LK entfernt. Bei 15 (13%) Patienten wurden Metastasen gefunden: A. iliaca externa 19%, A. iliaca interna 32%, Fossa obturatoria 36%, A. iliaca communis 7%, Marcille-Dreieck 3%, sakral 3%. In der Gruppe 2 ("high risk"; n=59) wurden durchschnittlich 23,9 LK entfernt. Bei 19 (32%) Patienten wurden Metastasen gefunden: A. iliaca externa 15%, A. iliaca interna 26%, Fossa obturatoria 19%, A. iliaca communis 29%, Marcille-Dreieck 6%, sakral 5%. Die volle Zahl LK-Metastasen war nachweisbar, wenn >15 LK in Gruppe 1 und >18 LK in Gruppe 2 entfernt wurden. Die PLND sollte um die A. iliaca communis, die A. iliaca interna, das Marcille-Dreieck und den sakralen Bereich erweitert werden. Bei "Intermediate-" und "High-risk-Patienten" sollten mindestens 15 bzw. 18 LK entfernt werden. We examined the quantity and localization of pelvic lymph node (LN) metastases in patients undergoing extended pelvic lymphadenectomy (ePLND). A total of 174 patients with intermediate and high-risk prostate cancer underwent radical prostatectomy (RP) and ePLND. We analyzed the relationship between the number of LNs removed and the number, frequency and topography of LN metastases. In group 1 (intermediate risk patients, n=115) the average number of LNs removed was 20.5, LN metastases were found in 15 patients (13 %) and the localizations were in the external iliac artery 19 %, the internal iliac artery 32 %, the obturator foramen 36 %, the common iliac artery 7 %, Marcille's triangle 3 % and sacral regions 3 %. In group 2 (high-risk patients, n=59) the average number of LNs removed was 23.9, LN metastases were found in 19 patients (32 %) and the localizations were the external iliac artery 15 %, the internal iliac artery 26 %, the obturator foramen 19 %, the common iliac artery 29 %, Marcille's triangle 6 % and sacral regions 5 %. The full number of metastases was detected only if more than 15 LNs were removed in group 1 and 18 LNs in group 2. At least 15 LNs in the intermediate risk group and at least 18 LNs in high risk group should be removed. The ePLND should include the common iliac artery,
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Der radikalen Prostatektomie und ePLND unterzogen sich 174 Patienten mit "Intermediate-" und "High-risk-Prostatakarzinom". Ausgewertet wurden Zahl der entfernten Lymphknoten (LK) sowie Zahl und Lage der Metastasen. In der Gruppe 1 ("intermediate risk"; n=115) wurden durchschnittlich 20,5 LK entfernt. Bei 15 (13%) Patienten wurden Metastasen gefunden: A. iliaca externa 19%, A. iliaca interna 32%, Fossa obturatoria 36%, A. iliaca communis 7%, Marcille-Dreieck 3%, sakral 3%. In der Gruppe 2 ("high risk"; n=59) wurden durchschnittlich 23,9 LK entfernt. Bei 19 (32%) Patienten wurden Metastasen gefunden: A. iliaca externa 15%, A. iliaca interna 26%, Fossa obturatoria 19%, A. iliaca communis 29%, Marcille-Dreieck 6%, sakral 5%. Die volle Zahl LK-Metastasen war nachweisbar, wenn &gt;15 LK in Gruppe 1 und &gt;18 LK in Gruppe 2 entfernt wurden. Die PLND sollte um die A. iliaca communis, die A. iliaca interna, das Marcille-Dreieck und den sakralen Bereich erweitert werden. Bei "Intermediate-" und "High-risk-Patienten" sollten mindestens 15 bzw. 18 LK entfernt werden. We examined the quantity and localization of pelvic lymph node (LN) metastases in patients undergoing extended pelvic lymphadenectomy (ePLND). A total of 174 patients with intermediate and high-risk prostate cancer underwent radical prostatectomy (RP) and ePLND. We analyzed the relationship between the number of LNs removed and the number, frequency and topography of LN metastases. In group 1 (intermediate risk patients, n=115) the average number of LNs removed was 20.5, LN metastases were found in 15 patients (13 %) and the localizations were in the external iliac artery 19 %, the internal iliac artery 32 %, the obturator foramen 36 %, the common iliac artery 7 %, Marcille's triangle 3 % and sacral regions 3 %. In group 2 (high-risk patients, n=59) the average number of LNs removed was 23.9, LN metastases were found in 19 patients (32 %) and the localizations were the external iliac artery 15 %, the internal iliac artery 26 %, the obturator foramen 19 %, the common iliac artery 29 %, Marcille's triangle 6 % and sacral regions 5 %. The full number of metastases was detected only if more than 15 LNs were removed in group 1 and 18 LNs in group 2. At least 15 LNs in the intermediate risk group and at least 18 LNs in high risk group should be removed. The ePLND should include the common iliac artery, the internal iliac artery, Marcille's triangle and sacral regions.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0340-2592</identifier><identifier>EISSN: 1433-0563</identifier><identifier>DOI: 10.1007/s00120-012-3005-4</identifier><language>ger</language><publisher>Heidelberg: Springer Nature B.V</publisher><ispartof>Urologe. 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Ausgewertet wurden Zahl der entfernten Lymphknoten (LK) sowie Zahl und Lage der Metastasen. In der Gruppe 1 ("intermediate risk"; n=115) wurden durchschnittlich 20,5 LK entfernt. Bei 15 (13%) Patienten wurden Metastasen gefunden: A. iliaca externa 19%, A. iliaca interna 32%, Fossa obturatoria 36%, A. iliaca communis 7%, Marcille-Dreieck 3%, sakral 3%. In der Gruppe 2 ("high risk"; n=59) wurden durchschnittlich 23,9 LK entfernt. Bei 19 (32%) Patienten wurden Metastasen gefunden: A. iliaca externa 15%, A. iliaca interna 26%, Fossa obturatoria 19%, A. iliaca communis 29%, Marcille-Dreieck 6%, sakral 5%. Die volle Zahl LK-Metastasen war nachweisbar, wenn &gt;15 LK in Gruppe 1 und &gt;18 LK in Gruppe 2 entfernt wurden. Die PLND sollte um die A. iliaca communis, die A. iliaca interna, das Marcille-Dreieck und den sakralen Bereich erweitert werden. Bei "Intermediate-" und "High-risk-Patienten" sollten mindestens 15 bzw. 18 LK entfernt werden. We examined the quantity and localization of pelvic lymph node (LN) metastases in patients undergoing extended pelvic lymphadenectomy (ePLND). A total of 174 patients with intermediate and high-risk prostate cancer underwent radical prostatectomy (RP) and ePLND. We analyzed the relationship between the number of LNs removed and the number, frequency and topography of LN metastases. In group 1 (intermediate risk patients, n=115) the average number of LNs removed was 20.5, LN metastases were found in 15 patients (13 %) and the localizations were in the external iliac artery 19 %, the internal iliac artery 32 %, the obturator foramen 36 %, the common iliac artery 7 %, Marcille's triangle 3 % and sacral regions 3 %. In group 2 (high-risk patients, n=59) the average number of LNs removed was 23.9, LN metastases were found in 19 patients (32 %) and the localizations were the external iliac artery 15 %, the internal iliac artery 26 %, the obturator foramen 19 %, the common iliac artery 29 %, Marcille's triangle 6 % and sacral regions 5 %. The full number of metastases was detected only if more than 15 LNs were removed in group 1 and 18 LNs in group 2. At least 15 LNs in the intermediate risk group and at least 18 LNs in high risk group should be removed. 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Ausgabe A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osmonov, Dk</au><au>Boller, A</au><au>Aksenov, A</au><au>Naumann, M</au><au>Jünemann, Kp</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>"Intermediate-risk-" und "High-risk-Prostatakarzinompatienten"</atitle><jtitle>Urologe. Ausgabe A</jtitle><date>2013-02-01</date><risdate>2013</risdate><volume>52</volume><issue>2</issue><spage>240</spage><pages>240-</pages><issn>0340-2592</issn><eissn>1433-0563</eissn><abstract>Wir haben die Häufigkeit von Lymphknotenmetastasen bei ausgedehnter pelviner Lymphadenektomie (ePLND) ausgewertet. Der radikalen Prostatektomie und ePLND unterzogen sich 174 Patienten mit "Intermediate-" und "High-risk-Prostatakarzinom". Ausgewertet wurden Zahl der entfernten Lymphknoten (LK) sowie Zahl und Lage der Metastasen. In der Gruppe 1 ("intermediate risk"; n=115) wurden durchschnittlich 20,5 LK entfernt. Bei 15 (13%) Patienten wurden Metastasen gefunden: A. iliaca externa 19%, A. iliaca interna 32%, Fossa obturatoria 36%, A. iliaca communis 7%, Marcille-Dreieck 3%, sakral 3%. In der Gruppe 2 ("high risk"; n=59) wurden durchschnittlich 23,9 LK entfernt. Bei 19 (32%) Patienten wurden Metastasen gefunden: A. iliaca externa 15%, A. iliaca interna 26%, Fossa obturatoria 19%, A. iliaca communis 29%, Marcille-Dreieck 6%, sakral 5%. Die volle Zahl LK-Metastasen war nachweisbar, wenn &gt;15 LK in Gruppe 1 und &gt;18 LK in Gruppe 2 entfernt wurden. Die PLND sollte um die A. iliaca communis, die A. iliaca interna, das Marcille-Dreieck und den sakralen Bereich erweitert werden. Bei "Intermediate-" und "High-risk-Patienten" sollten mindestens 15 bzw. 18 LK entfernt werden. We examined the quantity and localization of pelvic lymph node (LN) metastases in patients undergoing extended pelvic lymphadenectomy (ePLND). A total of 174 patients with intermediate and high-risk prostate cancer underwent radical prostatectomy (RP) and ePLND. We analyzed the relationship between the number of LNs removed and the number, frequency and topography of LN metastases. In group 1 (intermediate risk patients, n=115) the average number of LNs removed was 20.5, LN metastases were found in 15 patients (13 %) and the localizations were in the external iliac artery 19 %, the internal iliac artery 32 %, the obturator foramen 36 %, the common iliac artery 7 %, Marcille's triangle 3 % and sacral regions 3 %. 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