Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age

Background Diabetes mellitus (DM) has long been recognized as a risk factor for pancreatic cancer (PaC) and recently has attracted attention as a manifestation of PaC. Diabetes is expected to be a clue for the early detection of PaC; however, no effective screening strategy has been established. Met...

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Bibliographic Details
Published in:Journal of gastroenterology 2013-02, Vol.48 (2), p.238-246
Main Authors: Mizuno, Suguru, Nakai, Yousuke, Isayama, Hiroyuki, Yanai, Ayako, Takahara, Naminatsu, Miyabayashi, Koji, Yamamoto, Keisuke, Kawakubo, Kazumichi, Mohri, Dai, Kogure, Hirofumi, Sasaki, Takashi, Yamamoto, Natsuyo, Sasahira, Naoki, Hirano, Kenji, Tsujino, Takeshi, Ijichi, Hideaki, Tateishi, Keisuke, Akanuma, Masao, Tada, Minoru, Koike, Kazuhiko
Format: Article
Language:English
Subjects:
Abdominal Surgery
Age Distribution
Age of Onset
Aged
Biliary Tract
Body Mass Index
Body weight
Cancer
Case-Control Studies
Colorectal Surgery
Comparative analysis
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Diabetics
Diagnosis
Early Detection of Cancer - methods
Female
Gastroenterology
Genetic Predisposition to Disease
Health aspects
Hepatology
Humans
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Original Article—Liver
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Pancreatic Neoplasms - genetics
Risk Factors
Surgical Oncology
Time Factors
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Summary:Background Diabetes mellitus (DM) has long been recognized as a risk factor for pancreatic cancer (PaC) and recently has attracted attention as a manifestation of PaC. Diabetes is expected to be a clue for the early detection of PaC; however, no effective screening strategy has been established. Methods Forty diabetic patients with PaC were identified and compared with 120 diabetic patients without any malignancies. We analyzed risk factors for and early signs of PaC, focusing on the DM-onset age. Results As there were peaks at 40–45 years and 60–65 years in the distribution of DM-onset age, we analyzed the clinical characteristics of and risk factors for PaC according to DM-onset age: i.e., early-onset (
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-012-0622-z