The Oxidized Low-Density Lipoprotein/ [beta]2-Glycoprotein I Complex Is Associated with Abdominal Obesity in Healthy Middle-Aged Men

Background/Aims: Oxidized low-density lipoprotein (oxLDL) in complex with β2-glycoprotein I (β2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/β2GPI complexe...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2013-01, Vol.62 (1), p.7
Main Authors: Kraml, Pavel J, Syrovátka, Petr, Potocková, Jana, Andel, Michal
Format: Article
Language:English
Subjects:
Abdomen
Endothelium
Inflammatory diseases
Insulin resistance
Low density lipoprotein
Mens health
Middle age
Obesity
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Summary:Background/Aims: Oxidized low-density lipoprotein (oxLDL) in complex with β2-glycoprotein I (β2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/β2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/β2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. Methods: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. Results: The obese men demonstrated higher oxLDL/β2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/β2GPI correlated with more insulin resistance parameters compared to AOPP, thioredoxin or oxLDL. Furthermore, oxLDL/β2GPI was associated with plasminogen activator inhibitor-I (PAI-I; r = 0.365, p < 0.001) and negatively with interleukin-8 (r = -0.297, p < 0.05). Conclusions: In summary, oxLDL/β2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. The independent positive correlation with PAI-I indicates that oxLDL/β2GPI may serve as an early marker of low-grade inflammation and atherosclerosis initiation.[PUBLICATION ABSTRACT]
ISSN:0250-6807
1421-9697
DOI:10.1159/000343049