Effect of Nicotine Replacement on the Cigarette Withdrawal Syndrome

Summary The effect of nicotine replacement on the cigarette withdrawal syndrome was investigated in 48 smokers, who were randomly allocated to chew either 2 mg or.5 mg nicotine gum over 24 hours of cigarette abstinence. Characteristic withdrawal symptoms were observed on the low dose (.5 mg) gum: i....

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Bibliographic Details
Published in:British Journal of Addiction 1984-06, Vol.79 (2), p.215-219
Main Authors: West, R. J., Jarvis, M. J., Russell, M. A. H., Carruthers, M. E., Feyerabend, C.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chewing Gum
Dose-Response Relationship, Drug
Female
Humans
Male
Medical sciences
Nicotine - therapeutic use
Smoking
Substance Withdrawal Syndrome - drug therapy
Tobacco, tobacco smoking
Toxicology
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Summary:Summary The effect of nicotine replacement on the cigarette withdrawal syndrome was investigated in 48 smokers, who were randomly allocated to chew either 2 mg or.5 mg nicotine gum over 24 hours of cigarette abstinence. Characteristic withdrawal symptoms were observed on the low dose (.5 mg) gum: i.e. increased irritability, depression, restlessness, dizziness and hunger, and decreased ability to concentrate, sociability and composure when in company. In addition there was a drop in heart rate and urinary adrenaline excretion. The 2 mg gum alleviated problems of irritability, depression, and difficulties related to social interaction but not hunger or ability to concentrate. It also reduced the drop in heart rate from 14.9 to 9.7 bpm. The results support the view that nicotine deprivation per se plays a significant role in certain withdrawal effects.
ISSN:0952-0481
0965-2140
2056-5178
DOI:10.1111/j.1360-0443.1984.tb00265.x