Cardiovascular effects of two amides (Piperine and Piperdardine) isolated from Piper tuberculatum Jacq

Cardiovascular activity of the fraction from the plant Piper tuberculatum, containing two amides, piperine and piperdardine (PTPP) was evaluated in this work. Intravenous injection of PTPP (1.5; 2.5 and 5.0 mg/kg, i.v.) in normotensive rats reduced the diastolic blood pressure (DBP) and heart hate (...

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Bibliographic Details
Published in:Emirates journal of food and agriculture 2011-06, Vol.23 (3), p.265
Main Authors: de Araújo, João X, Ribeiro, Êurica Adélia N, da Silva, Sâmia Andrîcia S, da Costa, Cintia Danieli F, Alexandre-Moreira, Magna Suzana, Santos, Bárbara V O, Chaves, Maria Célia de O, de Medeiros, Isac A
Format: Article
Language:English
Subjects:
Blood pressure
Catheters
Coronary vessels
Drug dosages
Endothelium
Experiments
Heart rate
Hemodynamics
Laboratory animals
Metabolites
Muscular system
Rodents
Smooth muscle
Sodium
Veins & arteries
Ventilators
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Summary:Cardiovascular activity of the fraction from the plant Piper tuberculatum, containing two amides, piperine and piperdardine (PTPP) was evaluated in this work. Intravenous injection of PTPP (1.5; 2.5 and 5.0 mg/kg, i.v.) in normotensive rats reduced the diastolic blood pressure (DBP) and heart hate (HR) in a dose dependent manner. This effect was affected in rats treated with methysergide (5 mg/Kg, i.v), an inespecific serotonergic antagonist. In anesthetized and ventilated animals, PTPP lowered the DBP and the HR in a significative manner. However these effects were completely abolished after bilateral cervical vagotomy. The PTPP relaxed phenylephrine or KCl 80 mM pre-contracted rat aortic artery rings both with intact or denuded endothelium. This response was independent of the presence of a functional vascular endothelium. These results taken together, suggest that the hypotension and bradicardia observed after PTPP is probably due to direct cardiac activation and as a result of a direct spasmolytic effect. [PUBLICATION ABSTRACT]
ISSN:2079-052X
2079-0538