Evaluation of retrobulbar hemodynamics and aqueous humor levels of Endothelin‐1 in exfoliation syndrome, exfoliative glaucoma and primary open‐angle glaucoma

Purpose To compare mean Endothelin‐1 (ET‐1) concentration in aqueous humor and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS), exfoliative glaucoma (XFG), primary open‐angle glaucoma (POAG), and normal controls, and to evaluate the role of these index in the management of glauc...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2012-09, Vol.90 (s249), p.0-0
Main Authors: NASR, MB, KOUKOULA, SC, TRANOS, PG, LABIRIS, G, KOZOBOLIS, VP
Format: Article
Language:English
Subjects:
Glaucoma
Medical treatment
Ophthalmology
Online Access:Get full text
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Summary:Purpose To compare mean Endothelin‐1 (ET‐1) concentration in aqueous humor and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS), exfoliative glaucoma (XFG), primary open‐angle glaucoma (POAG), and normal controls, and to evaluate the role of these index in the management of glaucoma. Methods Aqueous Humour samples were collected from 20 subjects with POAG, 18 with XFG, 20 with XFS and 19 with senile cataract (CONTROL). Pre‐surgery Color Doppler Imaging (CDI) in Ophthalmic Artery (OA), Posterior Ciliary Arteries (PCA) and Central Retinal Artery (CRA) were performed. Samples were frozen at ‐70oC and were analyzed with ELISA method. Results ET‐1 level in aqueous samples of XFS, POAG, and XFG groups were statistically higher than that in CONTROL group (p1=0,008, p2=0,005, p3=0,020). However, there was no significant difference between aqueous ET‐1 levels of the three glaucoma groups (p< 0,900). Mean EDV of Ophthalmic Artery in subjects with XFG was significantly lower (p
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2012.2654.x