Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks: e1000788

Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical...

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Bibliographic Details
Published in:PLoS computational biology 2010-05, Vol.6 (5)
Main Authors: Audouze, Karine, Juncker, Agnieszka Sierakowska, Roque, S SA, Krysiak-Baltyn, Konrad, Weinhold, Nils, Taboureau, Olivier, Jensen, Thomas Skøt, Brunak, Søren
Format: Article
Language:English
Subjects:
Biology
Chemicals
Disease
Kinases
Pesticides
Proteins
Reproductive system
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Summary:Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types.
ISSN:1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1000788