Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels: e1001045

Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal...

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Bibliographic Details
Published in:PLoS genetics 2010-08, Vol.6 (8)
Main Authors: Meyer, Tamra E, Verwoert, Germaine C, Hwang, Shih-Jen, Glazer, Nicole L, Smith, Albert V, Rooij, J Avan, Ehret, Georg B, Boerwinkle, Eric, Felix, Janine F, Leak, Tennille S, Harris, Tamara B, Yang, Qiong, Dehghan, Abbas, Aspelund, Thor, Katz, Ronit, Homuth, Georg, Kocher, Thomas, Rettig, Rainer, Ried, Janina S, Gieger, Christian, Prucha, Hanna, Pfeufer, Arne, Meitinger, Thomas, Coresh, Josef, Hofman, Albert, Sarnak, Mark J, Chen, Yii-Der Ida, Uitterlinden, André G, Chakravarti, Aravinda, Psaty, Bruce M, Duijn, Cornelia Mvan, Kao, W HLinda, Witteman, Jacqueline CM, Gudnason, Vilmundur, Siscovick, David S, Fox, Caroline S, Köttgen, Anna, Glucose, Meta Analysisof
Format: Article
Language:English
Subjects:
Bone density
Genetics
Genomics
Magnesium
Medical research
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Summary:Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal physiologic variation in serum concentrations of these cations, we conducted genome-wide association studies of serum magnesium, potassium, and sodium concentrations using ~2.5 million genotyped and imputed common single nucleotide polymorphisms (SNPs) in 15,366 participants of European descent from the international CHARGE Consortium. Study-specific results were combined using fixed-effects inverse-variance weighted meta-analysis. SNPs demonstrating genome-wide significant (p
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1001045