Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels: e1001045

Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal...

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Published in:PLoS genetics 2010-08, Vol.6 (8)
Main Authors: Meyer, Tamra E, Verwoert, Germaine C, Hwang, Shih-Jen, Glazer, Nicole L, Smith, Albert V, Rooij, J Avan, Ehret, Georg B, Boerwinkle, Eric, Felix, Janine F, Leak, Tennille S, Harris, Tamara B, Yang, Qiong, Dehghan, Abbas, Aspelund, Thor, Katz, Ronit, Homuth, Georg, Kocher, Thomas, Rettig, Rainer, Ried, Janina S, Gieger, Christian, Prucha, Hanna, Pfeufer, Arne, Meitinger, Thomas, Coresh, Josef, Hofman, Albert, Sarnak, Mark J, Chen, Yii-Der Ida, Uitterlinden, André G, Chakravarti, Aravinda, Psaty, Bruce M, Duijn, Cornelia Mvan, Kao, W HLinda, Witteman, Jacqueline CM, Gudnason, Vilmundur, Siscovick, David S, Fox, Caroline S, Köttgen, Anna, Glucose, Meta Analysisof
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Bone density
Genetics
Genomics
Magnesium
Medical research
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container_title PLoS genetics
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creator Meyer, Tamra E
Verwoert, Germaine C
Hwang, Shih-Jen
Glazer, Nicole L
Smith, Albert V
Rooij, J Avan
Ehret, Georg B
Boerwinkle, Eric
Felix, Janine F
Leak, Tennille S
Harris, Tamara B
Yang, Qiong
Dehghan, Abbas
Aspelund, Thor
Katz, Ronit
Homuth, Georg
Kocher, Thomas
Rettig, Rainer
Ried, Janina S
Gieger, Christian
Prucha, Hanna
Pfeufer, Arne
Meitinger, Thomas
Coresh, Josef
Hofman, Albert
Sarnak, Mark J
Chen, Yii-Der Ida
Uitterlinden, André G
Chakravarti, Aravinda
Psaty, Bruce M
Duijn, Cornelia Mvan
Kao, W HLinda
Witteman, Jacqueline CM
Gudnason, Vilmundur
Siscovick, David S
Fox, Caroline S
Köttgen, Anna
Glucose, Meta Analysisof
description Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal physiologic variation in serum concentrations of these cations, we conducted genome-wide association studies of serum magnesium, potassium, and sodium concentrations using ~2.5 million genotyped and imputed common single nucleotide polymorphisms (SNPs) in 15,366 participants of European descent from the international CHARGE Consortium. Study-specific results were combined using fixed-effects inverse-variance weighted meta-analysis. SNPs demonstrating genome-wide significant (p
doi_str_mv 10.1371/journal.pgen.1001045
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subjects Bone density
Genetics
Genomics
Magnesium
Medical research
title Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels: e1001045
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