Evolutionary Breakpoints in the Gibbon Suggest Association between Cytosine Methylation and Karyotype Evolution: e1000538

Gibbon species have accumulated an unusually high number of chromosomal changes since diverging from the common hominoid ancestor 15-18 million years ago. The cause of this increased rate of chromosomal rearrangements is not known, nor is it known if genome architecture has a role. To address this q...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2009-06, Vol.5 (6)
Main Authors: Carbone, Lucia, Harris, R Alan, Vessere, Gery M, Mootnick, Alan R, Humphray, Sean, Rogers, Jane, Kim, Sung K, Wall, Jeffrey D, Martin, David, Jurka, Jerzy, Milosavljevic, Aleksandar, Jong, Pieter Jde
Format: Article
Language:English
Subjects:
Cancer
Cloning
Epigenetics
Evolution
Genetics
Genomes
Genomics
Monkeys & apes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gibbon species have accumulated an unusually high number of chromosomal changes since diverging from the common hominoid ancestor 15-18 million years ago. The cause of this increased rate of chromosomal rearrangements is not known, nor is it known if genome architecture has a role. To address this question, we analyzed sequences spanning 57 breaks of synteny between northern white-cheeked gibbons (Nomascus l. leucogenys) and humans. We find that the breakpoint regions are enriched in segmental duplications and repeats, with Alu elements being the most abundant. Alus located near the gibbon breakpoints (
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1000538