A comparison between metformin and garlic on alloxan-induced diabetic dogs

The present study was carried out to investigate the hypoglycaemic effects of metformin and garlic ( Allium sativum Linn) in alloxan-induced diabetic dogs. The anti-diabetic activity of garlic had never been investigated in experimental diabetic dogs. Twenty-one adult dogs were randomly allocated in...

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Bibliographic Details
Published in:Comparative clinical pathology 2013-03, Vol.22 (2), p.169-174
Main Authors: Mosallanejad, Bahman, Avizeh, Reza, Varzi, Hossein Najafzadeh, Pourmahdi, Mehdi
Format: Article
Language:English
Subjects:
Hematology
Medicine
Medicine & Public Health
Oncology
Original Article
Pathology
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Summary:The present study was carried out to investigate the hypoglycaemic effects of metformin and garlic ( Allium sativum Linn) in alloxan-induced diabetic dogs. The anti-diabetic activity of garlic had never been investigated in experimental diabetic dogs. Twenty-one adult dogs were randomly allocated into three equal groups consisting of seven dogs. The first group was the diabetic control, the second was the metformin treated and the third was the garlic-treated group. This study aimed to test 14-day oral administration of garlic (100 mg/kg) for its effects in alloxan-induced diabetic dogs in comparison with metformin (1,700 mg/dog/day) anti-diabetic activity. The mean decrease in blood glucose was 9.27 mg/dl for metformin and 25.93 mg/dl for garlic. The results showed that treatment with metformin non-significantly reduced blood glucose level ( p  > 0.05) and significantly increased serum insulin level in diabetic dogs ( p  
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-011-1381-6