99mTc-labelled human serum albumin cannot replace 125I-labelled human serum albumin to determine plasma volume in patients with liver disease

Summary Background and aims Determination of plasma volume (PV) is important in several clinical situations. Thus, patients with liver disease often have augmented PV as part of their sodium–water retention. This study was undertaken to compare PV determination by two indicators: technetium‐labelled...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2013-05, Vol.33 (3), p.211-217
Main Authors: Henriksen, Ulrik Lütken, Henriksen, Jens H., Bendtsen, Flemming, Møller, Søren
Format: Article
Language:English
Subjects:
cirrhosis
indicator heterogeneity
intravascular indicators
plasma volume determination
volume of distribution
Online Access:Get full text
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Summary:Summary Background and aims Determination of plasma volume (PV) is important in several clinical situations. Thus, patients with liver disease often have augmented PV as part of their sodium–water retention. This study was undertaken to compare PV determination by two indicators: technetium‐labelled human serum albumin (99mTc‐HSA) and iodine‐labelled human serum albumin (125I‐HSA), as the former may have advantages at repeated measurements and the latter is the classical gold standard. Study population and methods In 88 patients, (64 with liver disease, mainly cirrhosis, and 24 patients without liver disease), simultaneous measurements of PV were taken with 99mTc‐HSA and 125I‐HSA after 1 h in the supine position. Blood samples were obtained before and 10 min after quantitative injection of the two indicators. In a subset of patients (n = 32), the measurements were repeated within 1 h. Results In all patients, a close correlation was present between PV determined by the two indicators (r = 0·89, P
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12015