Synthesis and Antitubercular Evaluation of N-Arylpyrazine and N,N′-Alkyl-diylpyrazine-2-carboxamide Derivatives

Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug P...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2012-11, Vol.49 (6), p.1317-1322
Main Authors: Bispo, Marcelle de Lima Ferreira, Gonçalves, Raoni Schroeder Borges, Lima, Camilo Henrique da Silva, Cardoso, Laura Nogueira de Faria, Lourenço, Maria Cristina Silva, de Souza, Marcus Vinícius Nora
Format: Article
Language:English
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Summary:Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (>100 μg/mL). The obtained activities can be considered promising results, which characterizes these compounds as good start points to development of new antitubercular agents.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.921