Clinicopathologic significance of [beta]-catenin and matrix metalloproteinase-2 expression in non-small cell lung cancer

The purpose of this study was to analyze [beta]-catenin and matrix metalloproteinase-2 (MMP-2) expression in non-small cell lung cancer (NSCLC) and to investigate the association between their expression and clinicopathologic characteristics of NSCLC patients. Immunohistochemistry was performed to e...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2013-03, Vol.30 (1), p.1
Main Authors: Li, Guang-hu, Cui, Yong-sheng, Wu, Qi-yu, Zhang, Xiong-ji, Gao, Yu-fei
Format: Article
Language:English
Subjects:
Lung cancer
Oncology
Online Access:Get full text
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Summary:The purpose of this study was to analyze [beta]-catenin and matrix metalloproteinase-2 (MMP-2) expression in non-small cell lung cancer (NSCLC) and to investigate the association between their expression and clinicopathologic characteristics of NSCLC patients. Immunohistochemistry was performed to examine [beta]-catenin and MMP-2 protein expression in 39 resected NSCLC samples and 8 adjacent normal lung tissues. Statistical analysis with SPSS13.0 software was performed to investigate the association between [beta]-catenin and MMP-2 expression and clinicopathologic features of the patients. Expression of cytosolic [beta]-catenin in NSCLC tissue was significantly higher than that in normal tissues (PÂ
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-012-0437-z