Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer

To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of ^sup 11^C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). We included 185 patients with BCR after RP (PSAÂ >0.2Â ng/ml) or after E...

Full description

Saved in:
Bibliographic Details
Published in:World journal of urology 2013-04, Vol.31 (2), p.319
Main Authors: Rybalov, Maxim, Breeuwsma, Anthonius J, Leliveld, Anna M, Pruim, Jan, Dierckx, Rudi A, de Jong, Igle J
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 2
container_start_page 319
container_title World journal of urology
container_volume 31
creator Rybalov, Maxim
Breeuwsma, Anthonius J
Leliveld, Anna M
Pruim, Jan
Dierckx, Rudi A
de Jong, Igle J
description To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of ^sup 11^C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). We included 185 patients with BCR after RP (PSAÂ >0.2Â ng/ml) or after EBRT (ASTRO definition). After injection of 400Â MBq ^sup 11^C-Choline i.v., a scan was made using the ECAT HRÂ +Â PET camera with CT fusion images or Siemens mCT PET/CT. Biopsy-proven histology, confirmative imaging (CT or bone scan) and/or clinical follow-up (PSA) were used as composite reference. Statistical analysis was performed using PASW Statistics 18. ^sup 11^C-Choline PET was positive in 124/185 cases (65Â %) (in 22/61 (36Â %) after RP, 102/124 (82Â %) after EBRT). In 79 patients a local recurrence was identified, and 45 patients showed locoregional metastases on PET/CT. In 20 cases a proven false-negative PET scan was observed. Positive PET scans were confirmed by histology in 87/124 (70Â %) cases, by confirmatory imaging in 34/124 (28Â %) and by clinical follow-up after salvage treatment in 3 (2Â %) cases. The ROC analysis to detect a recurrence showed significant difference in area under the curve (AUC) of tPSA 0.721(pÂ
doi_str_mv 10.1007/s00345-012-0908-z
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1324006460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2936960031</sourcerecordid><originalsourceid>FETCH-proquest_journals_13240064603</originalsourceid><addsrcrecordid>eNqNjM1OwzAQhC0EEuHnAbitxBXDOnaT9IgiENyQ4NzKOG7rKrGDvUEqb8Lb4iAegMvOauabYexK4K1ArO8SolQLjqLkuMSGfx2xQigpeVOX1TErsC4VV8tGnrKzlPaIoq5wUbDv52HUhiBsgALpHl5e72_mA12Y3nvnt0BusKB99-t-2j4YRwcIHjpL1pDLX9Rk07yxStMIQqxa3u5CblsYQ3IUM2MHl9IMUxjCNupxdwCXq9ZMMVpPMMaQKA-B0d7YeMFONrpP9vJPz9n148Nb-8Qz9zHZROt9mKLP0VrIUiFWqkL5P-oHtt1fmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1324006460</pqid></control><display><type>article</type><title>Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer</title><source>Springer Nature</source><creator>Rybalov, Maxim ; Breeuwsma, Anthonius J ; Leliveld, Anna M ; Pruim, Jan ; Dierckx, Rudi A ; de Jong, Igle J</creator><creatorcontrib>Rybalov, Maxim ; Breeuwsma, Anthonius J ; Leliveld, Anna M ; Pruim, Jan ; Dierckx, Rudi A ; de Jong, Igle J</creatorcontrib><description>To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of ^sup 11^C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). We included 185 patients with BCR after RP (PSA &gt;0.2 ng/ml) or after EBRT (ASTRO definition). After injection of 400 MBq ^sup 11^C-Choline i.v., a scan was made using the ECAT HR + PET camera with CT fusion images or Siemens mCT PET/CT. Biopsy-proven histology, confirmative imaging (CT or bone scan) and/or clinical follow-up (PSA) were used as composite reference. Statistical analysis was performed using PASW Statistics 18. ^sup 11^C-Choline PET was positive in 124/185 cases (65 %) (in 22/61 (36 %) after RP, 102/124 (82 %) after EBRT). In 79 patients a local recurrence was identified, and 45 patients showed locoregional metastases on PET/CT. In 20 cases a proven false-negative PET scan was observed. Positive PET scans were confirmed by histology in 87/124 (70 %) cases, by confirmatory imaging in 34/124 (28 %) and by clinical follow-up after salvage treatment in 3 (2 %) cases. The ROC analysis to detect a recurrence showed significant difference in area under the curve (AUC) of tPSA 0.721(p &lt; 0.001) and PSA velocity 0.730 (p &lt; 0.001). PSA doubling time showed no significant difference with an AUC of 0.542 (p = 0.354). Detection rates are &lt;50 % in tPSA &lt;2 ng/ml and/or PSA velocity &lt;1 ng/ml/year. Total serum PSA and PSA velocity have significant effect on the detection rates of ^sup 11^C-Choline PET/CT in men with a BCR after RP or EBRT.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-012-0908-z</identifier><language>eng</language><publisher>Berlin: Springer Nature B.V</publisher><ispartof>World journal of urology, 2013-04, Vol.31 (2), p.319</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Rybalov, Maxim</creatorcontrib><creatorcontrib>Breeuwsma, Anthonius J</creatorcontrib><creatorcontrib>Leliveld, Anna M</creatorcontrib><creatorcontrib>Pruim, Jan</creatorcontrib><creatorcontrib>Dierckx, Rudi A</creatorcontrib><creatorcontrib>de Jong, Igle J</creatorcontrib><title>Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer</title><title>World journal of urology</title><description>To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of ^sup 11^C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). We included 185 patients with BCR after RP (PSA &gt;0.2 ng/ml) or after EBRT (ASTRO definition). After injection of 400 MBq ^sup 11^C-Choline i.v., a scan was made using the ECAT HR + PET camera with CT fusion images or Siemens mCT PET/CT. Biopsy-proven histology, confirmative imaging (CT or bone scan) and/or clinical follow-up (PSA) were used as composite reference. Statistical analysis was performed using PASW Statistics 18. ^sup 11^C-Choline PET was positive in 124/185 cases (65 %) (in 22/61 (36 %) after RP, 102/124 (82 %) after EBRT). In 79 patients a local recurrence was identified, and 45 patients showed locoregional metastases on PET/CT. In 20 cases a proven false-negative PET scan was observed. Positive PET scans were confirmed by histology in 87/124 (70 %) cases, by confirmatory imaging in 34/124 (28 %) and by clinical follow-up after salvage treatment in 3 (2 %) cases. The ROC analysis to detect a recurrence showed significant difference in area under the curve (AUC) of tPSA 0.721(p &lt; 0.001) and PSA velocity 0.730 (p &lt; 0.001). PSA doubling time showed no significant difference with an AUC of 0.542 (p = 0.354). Detection rates are &lt;50 % in tPSA &lt;2 ng/ml and/or PSA velocity &lt;1 ng/ml/year. Total serum PSA and PSA velocity have significant effect on the detection rates of ^sup 11^C-Choline PET/CT in men with a BCR after RP or EBRT.[PUBLICATION ABSTRACT]</description><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNjM1OwzAQhC0EEuHnAbitxBXDOnaT9IgiENyQ4NzKOG7rKrGDvUEqb8Lb4iAegMvOauabYexK4K1ArO8SolQLjqLkuMSGfx2xQigpeVOX1TErsC4VV8tGnrKzlPaIoq5wUbDv52HUhiBsgALpHl5e72_mA12Y3nvnt0BusKB99-t-2j4YRwcIHjpL1pDLX9Rk07yxStMIQqxa3u5CblsYQ3IUM2MHl9IMUxjCNupxdwCXq9ZMMVpPMMaQKA-B0d7YeMFONrpP9vJPz9n148Nb-8Qz9zHZROt9mKLP0VrIUiFWqkL5P-oHtt1fmQ</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Rybalov, Maxim</creator><creator>Breeuwsma, Anthonius J</creator><creator>Leliveld, Anna M</creator><creator>Pruim, Jan</creator><creator>Dierckx, Rudi A</creator><creator>de Jong, Igle J</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20130401</creationdate><title>Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer</title><author>Rybalov, Maxim ; Breeuwsma, Anthonius J ; Leliveld, Anna M ; Pruim, Jan ; Dierckx, Rudi A ; de Jong, Igle J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_13240064603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rybalov, Maxim</creatorcontrib><creatorcontrib>Breeuwsma, Anthonius J</creatorcontrib><creatorcontrib>Leliveld, Anna M</creatorcontrib><creatorcontrib>Pruim, Jan</creatorcontrib><creatorcontrib>Dierckx, Rudi A</creatorcontrib><creatorcontrib>de Jong, Igle J</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Proquest Health &amp; Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rybalov, Maxim</au><au>Breeuwsma, Anthonius J</au><au>Leliveld, Anna M</au><au>Pruim, Jan</au><au>Dierckx, Rudi A</au><au>de Jong, Igle J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer</atitle><jtitle>World journal of urology</jtitle><date>2013-04-01</date><risdate>2013</risdate><volume>31</volume><issue>2</issue><spage>319</spage><pages>319-</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of ^sup 11^C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). We included 185 patients with BCR after RP (PSA &gt;0.2 ng/ml) or after EBRT (ASTRO definition). After injection of 400 MBq ^sup 11^C-Choline i.v., a scan was made using the ECAT HR + PET camera with CT fusion images or Siemens mCT PET/CT. Biopsy-proven histology, confirmative imaging (CT or bone scan) and/or clinical follow-up (PSA) were used as composite reference. Statistical analysis was performed using PASW Statistics 18. ^sup 11^C-Choline PET was positive in 124/185 cases (65 %) (in 22/61 (36 %) after RP, 102/124 (82 %) after EBRT). In 79 patients a local recurrence was identified, and 45 patients showed locoregional metastases on PET/CT. In 20 cases a proven false-negative PET scan was observed. Positive PET scans were confirmed by histology in 87/124 (70 %) cases, by confirmatory imaging in 34/124 (28 %) and by clinical follow-up after salvage treatment in 3 (2 %) cases. The ROC analysis to detect a recurrence showed significant difference in area under the curve (AUC) of tPSA 0.721(p &lt; 0.001) and PSA velocity 0.730 (p &lt; 0.001). PSA doubling time showed no significant difference with an AUC of 0.542 (p = 0.354). Detection rates are &lt;50 % in tPSA &lt;2 ng/ml and/or PSA velocity &lt;1 ng/ml/year. Total serum PSA and PSA velocity have significant effect on the detection rates of ^sup 11^C-Choline PET/CT in men with a BCR after RP or EBRT.[PUBLICATION ABSTRACT]</abstract><cop>Berlin</cop><pub>Springer Nature B.V</pub><doi>10.1007/s00345-012-0908-z</doi></addata></record>
fulltext fulltext
identifier ISSN: 0724-4983
ispartof World journal of urology, 2013-04, Vol.31 (2), p.319
issn 0724-4983
1433-8726
language eng
recordid cdi_proquest_journals_1324006460
source Springer Nature
title Impact of total PSA, PSA doubling time and PSA velocity on detection rates of ^sup 11^C-Choline positron emission tomography in recurrent prostate cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-24T02%3A01%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20total%20PSA,%20PSA%20doubling%20time%20and%20PSA%20velocity%20on%20detection%20rates%20of%20%5Esup%2011%5EC-Choline%20positron%20emission%20tomography%20in%20recurrent%20prostate%20cancer&rft.jtitle=World%20journal%20of%20urology&rft.au=Rybalov,%20Maxim&rft.date=2013-04-01&rft.volume=31&rft.issue=2&rft.spage=319&rft.pages=319-&rft.issn=0724-4983&rft.eissn=1433-8726&rft_id=info:doi/10.1007/s00345-012-0908-z&rft_dat=%3Cproquest%3E2936960031%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_13240064603%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1324006460&rft_id=info:pmid/&rfr_iscdi=true